الصفحة الرئيسية>>Signaling Pathways>> GPCR/G protein>> LPL Receptor>>ONO-9780307

ONO-9780307

رقم الكتالوجGC63128

ONO-9780307 هو مضاد LPA1 اصطناعي محدد (مستقبلات حمض الليزوفوسفاتيد 1) بقيمة IC50 تبلغ 2.7 نانومتر

Products are for research use only. Not for human use. We do not sell to patients.

ONO-9780307 التركيب الكيميائي

Cas No.: 856691-44-6

الحجم السعر المخزون الكميّة
5 mg
864٫00
متوفر
10 mg
1395٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Description of ONO-9780307

ONO-9780307 is a specific synthetic LPA1 (lysophosphatidic acid receptor 1) antagonist with an IC50 value of 2.7 nM[1].

VT107 (0.1~10000 μM; LPA1-B103 and Vector-B103 cells) results in inhibition of Ca2+ mobilization[1].ONO-9780307 is used to solve the LPA1 crystal structure, binds to an orthosteric site in LPA1[1].

[1]. Mizuno H, et al. Lysophospholipid G protein-coupled receptor binding parameters as determined by backscattering interferometry. J Lipid Res. 2019;60(1):212-217.

Chemical Properties of ONO-9780307

Cas No. 856691-44-6 SDF
Formula C30H35NO7 M.Wt 521.6
الذوبان DMSO : 190 mg/mL (364.26 mM; Need ultrasonic) Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of ONO-9780307

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.9172 mL 9.5859 mL 19.1718 mL
5 mM 0.3834 mL 1.9172 mL 3.8344 mL
10 mM 0.1917 mL 0.9586 mL 1.9172 mL
  • حاسبة المولارية

  • حاسبة التخفيف

  • Molecular Weight Calculator

كتلة
=
تركيز
x
مقدار
x
ميغاواط *
 
 
 
** عند إعداد حلول المخزون، دائمًا استخدم الوزن الجزيئي الخاص بالدفعة للمنتج على ملصق القارورة MSDS / CoA (متوفر عبر الإنترنت).

احسب

In vivo Formulation Calculator (Clear solution) of ONO-9780307

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

View current batch:

مراجعات

Review for ONO-9780307

Average Rating: 5 ★★★★★ (Based on Reviews and 17 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for ONO-9780307

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.