PNU288034 |
| رقم الكتالوجGC32259 |
PNU288034 هو مضاد حيوي قوي من أوكسازوليدينون
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 383199-88-0
Sample solution is provided at 25 µL, 10mM.
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PNU288034 is a potent oxazolidinone antibiotic.
In vitro studies conducted to characterize the transporters involved demonstrates PNU-288034 uptake by human organic anion transporter 3 (OAT3; Km = 44 +/- 5 μM) and human multidrug and toxin extrusion protein 1 (hMATE1; Km = 340 +/- 55 μM)[1].
PNU-288034 is metabolically stable in liver microsomes across species, and unchanged drug is cleared in the urine by an apparent active renal secretion process in rat and monkey. Coadministration of PNU-288034 and the OAT3 inhibitor probenecid significantly increases PNU-288034 plasma area under the curve (170%) and reduces both plasma and renal clearance in monkey. Coadministration of PNU-288034 and cimetidine also reduces plasma clearance in rat to a rate comparable with probenecid coadministration[1].
[1]. Lai Y, et al. Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44.
| Cas No. | 383199-88-0 | SDF | |
| Canonical SMILES | CC(NC[C@H]1CN(C2=CC(F)=C(N3CCS(CC3)(=O)=O)C(F)=C2)C(O1)=O)=O | ||
| Formula | C16H19F2N3O5S | M.Wt | 403.4 |
| الذوبان | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.4789 mL | 12.3946 mL | 24.7893 mL |
| 5 mM | 495.8 μL | 2.4789 mL | 4.9579 mL |
| 10 mM | 247.9 μL | 1.2395 mL | 2.4789 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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