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(R)-Oxybutynin hydrochloride

رقم الكتالوجGC71634

(R)-Oxybutynin hydrochloride، وهو أيزومر R-من هيدروكلوريد أوكسيبيوتينين، هو مضاد مستقبلات مسكاريني نشط عن طريق الفم.

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(R)-Oxybutynin hydrochloride التركيب الكيميائي

Cas No.: 1207344-05-5

الحجم السعر المخزون الكميّة
5 mg
128٫00
متوفر
10 mg
216٫00
متوفر
25 mg
455٫00
متوفر
50 mg
770٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of (R)-Oxybutynin hydrochloride

(R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride has antimuscarinic, antispasmodic and anticholinergic activity, competitively antagonizes Carbachol-induced contractions. (R)-Oxybutynin hydrochloride can be used for researching incontinence due to neurogenic bladder dysfunction. (R)-Oxybutynin (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References:
[1]. Smith ER, et al. Comparison of the antimuscarinic and antispasmodic actions of racemic oxybutynin and desethyloxybutynin and their enantiomers with those of racemic terodiline. Arzneimittelforschung. 1998 Oct;48(10):1012-8.
[2]. Siddiqui MA, et al. Oxybutynin extended-release: a review of its use in the management of overactive bladder. Drugs. 2004;64(8):885-912.
[3]. Zobrist RH, et al. Pharmacokinetics of the R- and S-enantiomers of oxybutynin and N-desethyloxybutynin following oral and transdermal administration of the racemate in healthy volunteers. Pharm Res. 2001 Jul;18(7):1029-34.

Chemical Properties of (R)-Oxybutynin hydrochloride

Cas No. 1207344-05-5 SDF
Formula C22H32ClNO3 M.Wt 393.95
الذوبان DMSO : 100 mg/mL (253.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Storage 4°C, sealed storage, away from moisture
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (R)-Oxybutynin hydrochloride

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.5384 mL 12.692 mL 25.3839 mL
5 mM 0.5077 mL 2.5384 mL 5.0768 mL
10 mM 0.2538 mL 1.2692 mL 2.5384 mL
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In vivo Formulation Calculator (Clear solution) of (R)-Oxybutynin hydrochloride

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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