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RA-2

رقم الكتالوجGC91410

RA-2 هو مثبط للقناة الكالسيومية المفعولة بالبوتاسيوم ذات الصغر (KCa2.3 / SK3) وقناة الكالسيومية المفعولة بالبوتاسيوم ذات التحدُّر المتوسط ​​(KCa3.1 / IK1) (IC50s = 2 و 17 نانومتر على الترتيب).

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RA-2 التركيب الكيميائي

Cas No.: 1867107-62-7

الحجم السعر المخزون الكميّة
5mg
80٫00
متوفر
10mg
151٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of RA-2

RA-2 is an inhibitor of small-conductance calcium-activated potassium channel 2.3 (KCa2.3/SK3) and intermediate-conductance calcium-activated potassium channel 3.1 (KCa3.1/IK1) (IC50s = 2 and 17 nM, respectively).1 It is selective for these channels over KCa1.1/BK1, voltage-gated potassium channel 1.2 (Kv1.2), Kv1.3, Kv7.4, human-ether-a-go-go (hERG), also known as Kv11.1, and the inward-rectifier potassium channel (Kir), but also inhibits KCa2.1 and KCa2.2 by 96 and 90%, respectively, at 1 µM. RA-2 (1 µM) inhibits bradykinin-induced relaxation of porcine coronary artery rings precontracted with the TP receptor agonist U-46619 . It decreases heart rate, but not mean arterial blood pressure, in mice when administered at a dose of 30 mg/kg.

Chemical Properties of RA-2

Cas No. 1867107-62-7 SDF
Formula C22H16F2O6 M.Wt 414.4
الذوبان DMSO: 5 mg/ml,Ethanol: 15 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of RA-2

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.4131 mL 12.0656 mL 24.1313 mL
5 mM 0.4826 mL 2.4131 mL 4.8263 mL
10 mM 0.2413 mL 1.2066 mL 2.4131 mL
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In vivo Formulation Calculator (Clear solution) of RA-2

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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