SL 0101-1 |
| رقم الكتالوجGC16313 |
SL 0101-1 (SL0101) ، جليكوسيد kaempferol ، معزول عن النبات الاستوائي F. refracta ، هو مثبط p90 Ribosomal S6 Kinase (RSK) نافذ للخلايا ، انتقائي ، قابل للانعكاس ، منافس لـ ATP ، مع IC50 من 89 نانومترSL 0101-1 (SL0101) هو مثبط انتقائي RSK1 / 2 ، مع Ki 1 ميكرومتر
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Cas No.: 77307-50-7
Sample solution is provided at 25 µL, 10mM.
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SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. Shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase[1].
References:
[1]. Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34.
| Cas No. | 77307-50-7 | SDF | |
| Chemical Name | (2S,3S,4S,5R,6S)-6-((5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl)oxy)-5-hydroxy-2-methyltetrahydro-2H-pyran-3,4-diyl diacetate | ||
| Canonical SMILES | C[C@@]1([H])[C@@](OC(C)=O)([H])[C@](OC(C)=O)([H])[C@](O)([H])[C@@](OC(C(C2=C(O)C=C(O)C=C2O3)=O)=C3C4=CC=C(O)C=C4)([H])O1 | ||
| Formula | C25H24O12 | M.Wt | 516.46 |
| الذوبان | DMF: 0.33 mg/ml,DMSO: 0.16 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.9363 mL | 9.6813 mL | 19.3626 mL |
| 5 mM | 0.3873 mL | 1.9363 mL | 3.8725 mL |
| 10 mM | 0.1936 mL | 0.9681 mL | 1.9363 mL |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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