الصفحة الرئيسية>>SN-38 Glucuronide (trifluoroacetate salt)

SN-38 Glucuronide (trifluoroacetate salt) (Synonyms: SN-38G)

رقم الكتالوجGC44906

SN-38 glucuronide is an inactive metabolite of irinotecan, which is a derivative of the alkaloid camptothecin.

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SN-38 Glucuronide (trifluoroacetate salt) التركيب الكيميائي

الحجم السعر المخزون الكميّة
1mg
796٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of SN-38 Glucuronide (trifluoroacetate salt)

SN-38 glucuronide is an inactive metabolite of irinotecan , which is a derivative of the alkaloid camptothecin. [1] SN-38 glucuronide is formed by glucuronidation of SN-38 , the active metabolite of irinotecan, by UDP glucuronosyl transferase 1A1 (UGT1A1) and UGT1A7. It can also be formed in COS-7 cells by UGT1A1 and UGT1A10, which are both up-regulated in an irinotecan/SN-38-resistant cell line. [2] 

Reference:
[1]. Mathijssen, R.H.J., van Alphen, R.J., Verweij, J., et al. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). Clin. Cancer Res. 7(8), 2182-2194 (2001).
[2]. Oguri, T., Takahashi, T., Miyazaki, M., et al. UGT1A10 is responsible for SN-38 glucuronidation and its expression in human lung cancers. Anticancer Res. 24(5A), 2893-2896 (2004).

Chemical Properties of SN-38 Glucuronide (trifluoroacetate salt)

Cas No. SDF
المرادفات SN-38G
Chemical Name (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl-β-D-glucopyranosiduronic acid, trifluoroacetate salt
Canonical SMILES O=C([C@]1(O)CC)OCC2=C1C=C(C(N=C(C=CC(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O3)=C4)C4=C5CC)=C5C6)N6C2=O.FC(F)(C(O)=O)F
Formula C28H28N2O11•XCF3COOH M.Wt 568.5
الذوبان Slightly soluble in DMSO, Slightly soluble in Methanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of SN-38 Glucuronide (trifluoroacetate salt)

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1 mg 5 mg 10 mg
1 mM 1.759 mL 8.7951 mL 17.5901 mL
5 mM 0.3518 mL 1.759 mL 3.518 mL
10 mM 0.1759 mL 0.8795 mL 1.759 mL
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In vivo Formulation Calculator (Clear solution) of SN-38 Glucuronide (trifluoroacetate salt)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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