الصفحة الرئيسية>>Signaling Pathways>> Toxins>>Swinholide A

Swinholide A

رقم الكتالوجGC44976

Swinholide A هو البولي كيتيد البحري المرتبط بالأكتين ويقلل الأكتين مع Kd البالغ حوالي 50 نانومتر

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Swinholide A التركيب الكيميائي

Cas No.: 95927-67-6

الحجم السعر المخزون الكميّة
10μg
161٫00
متوفر
50μg
483٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of Swinholide A

Swinholide A is a natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells. [1] [2] It stabilizes actin dimers and also binds to and severs F-actin filaments.[1] [3]  Swinholide A binds to G-actin in a 1:2 molar ratio and decreases the rate of nucleotide exchange in G-actin. [2]

Reference:
[1]. Bubb, M.R., Spector, I., Bershadsky, A.D., et al. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. The Journal of Biological Chemisty 270(8), 3463-3466 (1995).
[2]. Saito, S.y., Watabem, S., Ozaki, H., et al. Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A. Journal of Biochemistry 123(4), 571-578 (1998).
[3]. Terry, D.R., Higa, T., and Bubb, M.R. Misakinolide A is a marine macrolide that caps but does not sever filamentous actin. The Journal of Biological Chemisty 272(12), 7841-7845 (1997)

Chemical Properties of Swinholide A

Cas No. 95927-67-6 SDF
Chemical Name (1R,3S,5E,7E,11S,12S,13R,15S,16S,17S,19S,23R,25S,27E,29E,33S,34S,35R,37S,38S,39S,41S)-3,13,15,25,35,37-hexahydroxy-11,33-bis[(1S,2S,3S)-2-hydroxy-1,3-dimethyl-5-[(2S,4R,6S)-tetrahydro-4-methoxy-6-methyl-2H-pyran-2-yl]pentyl]-17,39-dimethoxy-6,12,16,28,34,38-hexamethyl-10,32,45,46-tetraoxatricyclo[39.3.1.119,23]hexatetraconta-5,7,21,27,29,43-hexaene-9,31-dione
Canonical SMILES C[C@@H]([C@H]([C@H](CC[C@@H]1O[C@H](C[C@@H](OC)C1)C)C)O)C([C@@H](C)[C@H](O)C[C@H](O)[C@H](C)[C@@H](OC)C[C@]2(O[C@@]([H])(C=CC2)C[C@@H](O)C/C=C(C)/C=C/C(OC([C@H]3C)[C@H]([C@H]([C@H](CC[C@@H]4O[C@H](C[C@@H](OC)C4)C)C)O)C)=O)[H])OC(/C=C/C(C)=C/C[C@H](O)
Formula C78H132O20 M.Wt 1389.9
الذوبان Soluble in methanol, ethanol, DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Swinholide A

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1 mg 5 mg 10 mg
1 mM 0.7195 mL 3.5974 mL 7.1948 mL
5 mM 0.1439 mL 0.7195 mL 1.439 mL
10 mM 0.0719 mL 0.3597 mL 0.7195 mL
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In vivo Formulation Calculator (Clear solution) of Swinholide A

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 10 reference(s) in Google Scholar.)

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