الصفحة الرئيسية>>Signaling Pathways>> GPCR/G protein>> GPBA Receptor>>TC-G 1005

TC-G 1005

رقم الكتالوجGC50107

TC-G 1005 هو ناهض قوي وانتقائي ونشط عن طريق الفم لمستقبل BA Takeda G المقترن بالبروتين 5 (TGR5) ، مع EC50s من 0.72 و 6.2 نانومتر لـ hTGR5 و mTGR5 ، على التوالي

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TC-G 1005 التركيب الكيميائي

Cas No.: 1415407-60-1

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
59٫00
متوفر
1mg
31٫00
متوفر
5mg
67٫00
متوفر
10mg
109٫00
متوفر
25mg
223٫00
متوفر
50mg
331٫00
متوفر
100mg
470٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

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  • GlpBio Citations

    GlpBio Citations
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Sample solution is provided at 25 µL, 10mM.

Description of TC-G 1005

Potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.

Duan et al (2012) Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J.Med.Chem. 55 10475 PMID:23148522

Chemical Properties of TC-G 1005

Cas No. 1415407-60-1 SDF
Canonical SMILES CC1=CC(OC2=CC=NC=C2C(N3C(C=CC=C4)=C4N(C5CC5)CC3)=O)=C(C)C=C1
Formula C25H25N3O2 M.Wt 399.48
الذوبان DMSO : 33.33 mg/mL (83.43 mM; Need ultrasonic) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of TC-G 1005

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.5033 mL 12.5163 mL 25.0325 mL
5 mM 0.5007 mL 2.5033 mL 5.0065 mL
10 mM 0.2503 mL 1.2516 mL 2.5033 mL
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In vivo Formulation Calculator (Clear solution) of TC-G 1005

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 21 reference(s) in Google Scholar.)

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