الصفحة الرئيسية>>Signaling Pathways>> Microbiology & Virology>> HCV>>VCH-916

VCH-916 (Synonyms: VCH916;VCH 916)

رقم الكتالوجGC11830

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VCH-916 التركيب الكيميائي

Cas No.: 1200133-34-1

الحجم السعر المخزون الكميّة
5mg
135٫00
متوفر
10mg
180٫00
متوفر
50mg
540٫00
متوفر
100mg
990٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of VCH-916

VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.IC50 Value: Target: HCVVCH-916 is a novel allosteric inhibitor of HCV NS5B polymerase. The RNA-dependent RNA polymerase (NS5B) of HCV is one of the attractive validated targets for development of new drugs to block HCV infection. VCH-916 is currently being evaluated for safety/tolerability, pharmacokinetics and anti-viral efficacy in chronically infected HCV patient.

References:
[1]. Ludmila Gerber, Tania M. Welzel, Stefan Zeuzem. New therapeutic strategies in HCV: polymerase inhibitors. Liver International. 2013,33(s1): 85-92
[2]. Abdelrahman S. Mayhoub. Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure-activity and resistance relationships; different scaffolds and mutations. Bioorganic & Medicinal Chemistry. 2012, 20 (10): 3150-3161.
[3]. Debasis Dasa, Jian Honga, Shu-Hui Chena, et al. Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry. 2011, 19(16): 4690-4703
[4]. Pierre L Beaulieu. Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection. Informahealthcare. 2009, 19(2): 145-164
[5]. Safety,Tolerability and Pharmacokinetics of Multiple Ascending Doses of VCH 916 in Subjects With Chronic Hep C Infection

Chemical Properties of VCH-916

Cas No. 1200133-34-1 SDF
المرادفات VCH916;VCH 916
Chemical Name potassium 5-(cyclohex-1-en-1-yl)-3-(N-(4-methoxycyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate
Canonical SMILES CC1CCC(C(N(C2=C(C([O-])=O)SC(C3=CCCCC3)=C2)C4CCC(OC)CC4)=O)CC1.[K+]
Formula C26H36KNO4S M.Wt 497.73
الذوبان DMSO : 100 mg/mL (200.91 mM; Need ultrasonic) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of VCH-916

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.0091 mL 10.0456 mL 20.0912 mL
5 mM 0.4018 mL 2.0091 mL 4.0182 mL
10 mM 0.2009 mL 1.0046 mL 2.0091 mL
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In vivo Formulation Calculator (Clear solution) of VCH-916

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for VCH-916

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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