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Artemether (SM-224) Catalog No.GC12784

Semi-synthetic derivative of artemisinin

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10mM (in 1mL DMSO) Please Inquire Please Inquire
10mg Please Inquire Please Inquire
25mg Please Inquire Please Inquire
50mg Please Inquire Please Inquire
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 71963-77-4 SDF
Synonyms N/A
Chemical Name (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
Canonical SMILES [H][C@]12[C@@]3([C@@]4([H])CC[C@@]2([H])C)[C@@](O[C@H](OC)[C@@]4(C)[H])([H])O[C@@](OO3)(C)CC1
Formula C16H26O5 M.Wt 298.4
Solubility ≥15.3 mg/mL in DMSO, ≥90.2 mg/mL in EtOH, <2.3 mg/mL in H2O Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Artemether is a semi-synthetic derivative of artemisinin (qinghaosu), a naturally occurring peroxide lactone derived from a traditional Chinese herbal remedy Artemisia annua L., to enhance the solubility and antimalarial activity of its parental compound. Artemether exhibits potent antimalarial and antischistosomal activities against malarial parasites and Schistosoma japonicum infections. Although it has not been well elucidated, an endoperoxide bridge within the chemical structure of Artemether might be the key characteristic considered to be responsible for its antimalarial and antischistosomal activities, which can be metabolized by malarial or schistosomal parasites, under in vivo conditions, generating detrimental oxygen radicals to attack parasite macromolecules.


[1].Xiao Shuhua and Brian A. Catto.  In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 1989, 1557-1562