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Aspirin-d4 (Synonyms: Acetylsalicylic Acid-d4)

Catalog No.GC42859

Aspirin-d4 is intended for use as an internal standard for the quantification of aspirin by GC- or LC-MS.

Products are for research use only. Not for human use. We do not sell to patients.

Aspirin-d4 Chemical Structure

Cas No.: 97781-16-3

Size Price Stock Qty
1mg
$60.00
In stock
5mg
$240.00
In stock
10mg
$451.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Aspirin-d4 is intended for use as an internal standard for the quantification of aspirin by GC- or LC-MS. Aspirin is a non-selective, irreversible COX inhibitor. The IC50 values for ovine COX-1 and -2 are 0.75 and 1.25 mM, respectively. Aspirin acetylates COX-1 at Ser530 and COX-2 at Ser516 resulting in irreversible enzyme inhibition.

Chemical Properties

Cas No. 97781-16-3 SDF
Synonyms Acetylsalicylic Acid-d4
Canonical SMILES OC(C1=C(OC(C)=O)C([2H])=C([2H])C([2H])=C1[2H])=O
Formula C9H4D4O4 M.Wt 184.2
Solubility DMF: >30 mg/ml,DMSO: > 41 mg/ml,Ethanol: > 80 mg/ml,PBS (pH 7.2): > 2.7 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 5.4289 mL 27.1444 mL 54.2888 mL
5 mM 1.0858 mL 5.4289 mL 10.8578 mL
10 mM 0.5429 mL 2.7144 mL 5.4289 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 6 reference(s) in Google Scholar.)

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