Home>>Azetidine-2-carboxylic acid
Azetidine-2-carboxylic acid Catalog No.GC33415

Size Price Stock Qty
10mM*1mLinDMSO
$50.00
In stock
100mg
$46.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 2517-04-6 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C(O)C1NCC1
Formula C4H7NO2 M.Wt 101.1
Solubility H2O : 50 mg/mL (494.56 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent[1][2].

Azetidine-2-carboxylic acid (375-5oo μg per day) is incorporated into the collagen synthesized by chick embryo cartilage in vitro[3].

[1]. Rubenstein E, et al. Azetidine-2-carboxylic acid in the food chain. Phytochemistry. 2009 Jan;70(1):100-4. [2]. Rubenstein E, et al. Misincorporation of the proline analog azetidine-2-carboxylic acid in the pathogenesis of multiple sclerosis: a hypothesis. J Neuropathol Exp Neurol. 2008 Nov;67(11):1035-40. [3]. Lane JM, et al. Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos. Biochim Biophys Acta. 1971 Jun 29;236(3):517-27.