Home>>Signaling Pathways>> MAPK Signaling>> Raf>>B-Raf IN 1
B-Raf IN 1 Catalog No.GC10534

B-Raf inhibitor

Size Price Stock Qty
Ship Within 10-14 Days

Customer Review

Based on customer reviews.

Tel: (626) 353-8530 Email: sales@glpbio.com

Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

View current batch:

Chemical Properties

Cas No. 950736-05-7 SDF
Chemical Name (Z)-N-(3-(3-(4-((dimethylamino)methyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzimidic acid
Canonical SMILES CN(CC1=CC=C(C(C=NN23)=C3N=CC=C2C4=CC(/N=C(O)/C5=CC(C(F)(F)F)=CC=C5)=CC=C4)C=C1)C
Formula C29H24F3N5O M.Wt 515.53
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
  • Molarity Calculator

  • Dilution Calculator

**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).



B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.

B-Raf IN 1 (Compound 10n) inhibits WM 266-4 and HT29 cells with IC50s of 0.92 and 0.78 μM, respectively[1].

[1]. Berger DM, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.