Bafilomycin B1 (Synonyms: Setamycin) |
| Catalog No.GC18297 |
The bafilomycins are fungal plecomacrolide antibiotics with a 16-membered lactone ring.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 88899-56-3
Sample solution is provided at 25 µL, 10mM.
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The bafilomycins are fungal plecomacrolide antibiotics with a 16-membered lactone ring. They inhibit the growth of Gram-positive bacteria and fungi. Bafilomycin B1 is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range. It is at least 1,000-fold less potent at most other types of ATPases. When used at 100 nM, the related macrolide bafilomycin A1 blocks V-ATPase-mediated acidification of lysosomes during autophagy, preventing protein degradation. Remarkably, at only 1 nM, both bafilomycin A1 or B1 dramatically attenuate chloroquine-induced apoptosis of neurons without altering autophagy.
Review for Bafilomycin B1
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
Review for Bafilomycin B1
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