Bax Inhibitor Peptide V5 (trifluoroacetate salt) (Synonyms: BIP V5, VPMLK) |
| Catalog No.GC52476 |
A Bax inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Bax inhibitor peptide V5 is an inhibitor of Bax.1 It decreases levels of the pro-apoptotic proteins Bax, Bad, and NF-?B p65 and increases levels of the anti-apoptotic proteins X-linked inhibitor of apoptosis (XIAP) and Bcl-2 in isolated mouse pancreatic islets when used at a concentration of 100 µM.2 It inhibits apoptosis induced by etoposide in Hep3B human hepatoma cells when used at a concentration of 200 µM.1 Bax inhibitor peptide V5 (5 mg/ml, i.c.v.) decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test, indicating an improvement in sensorimotor function, in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation.3 Bax inhibitor peptide V5, when used at a concentration of 100 µM in syngeneic pancreatic islet cells prior to transplantation, inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in a mouse model of diabetes induced by streptozotocin .2
1.Yoshida, T., Tomioka, I., Nagahara, T., et al.Bax-inhibiting peptide derived from mouse and rat Ku70Biochem. Biophys. Res. Commun.321(4)961-966(2004) 2.Rivas-Carrillo, J.D., Soto-Gutierrez, A., Navarro-Alvarez, N., et al.Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in miceDiabetes56(5)1259-1267(2007) 3.Wang, X., Han, W., Du, X., et al.Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injuryStroke41(9)2050-2055(2010)
| Cas No. | SDF | ||
| Synonyms | BIP V5, VPMLK | ||
| Canonical SMILES | O=C([C@@H](N)C(C)C)N1[C@H](C(N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)CCC1.OC(C(F)(F)F)=O | ||
| Formula | C27H50N6O6S ? XCF3COOH | M.Wt | 586.8 |
| Solubility | DMF: 15mg/mL,DMSO: 20mg/mL,Ethanol: 20mg/mL,PBS (pH 7.2): 10mg/mL | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.7042 mL | 8.5208 mL | 17.0416 mL |
| 5 mM | 0.3408 mL | 1.7042 mL | 3.4083 mL |
| 10 mM | 0.1704 mL | 0.8521 mL | 1.7042 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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