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Berberine-d6 (chloride) (Synonyms: BBR-d6, Umbellatine-d6)

Catalog No.GC49387

An internal standard for the quantification of berberine

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Berberine-d6 (chloride) Chemical Structure

Cas No.: N/A

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1 mg
$476.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Berberine-d6 is intended for use as an internal standard for the quantification of berberine by GC- or LC-MS. Berberine is an isoquinoline alkaloid that has been found in C. fenestratum and has diverse biological activities.1,2,3,4,5 It induces frameshift mutations and gene crossovers in haploid and diploid strains of S. cerevisiae, respectively, in the exponential growth phase when used at a concentration of 50 µg/ml.2 Berberine is active against the S. aureus strains ATCC 25922 and NCTC 8530 (MIC = 250 µg/ml for both).3 It decreases contusion volume, ventricle enlargement, and neurological deficits in a mouse model of controlled cortical impact-induced traumatic brain injury (TBI) when administered at a dose of 10 mg/kg.4 Berberine (50 mg/kg) reduces serum LDL cholesterol levels in hamsters fed a high-fat high-cholesterol diet.5

1.Malhotra, S., Taneja, S.C., and Dhar, K.L.Minor alkaloid from Coscinium fenestratumPhytochem.28(7)1998-1999(1989) 2.Pasqual, M.S., Lauer, C.P., Moyna, P., et al.Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organismsMutat. Res.286(2)243-252(1993) 3.Iwasa, K., Kamigauchi, M., Ueki, M., et al.Antibacterial activity and structure-activity relationships of berberine analogsEur. J. Med. Chem.31(6)469-478(1996) 4.Chen, C.C., Hung, T.H., Lee, C.Y., et al.Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injuryPLoS One9(12)e115694(2014) 5.Kong, W., Wei, J., Abidi, P., et al.Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statinsNat. Med.10(12)1344-1351(2004)

Chemical Properties

Cas No. N/A SDF
Synonyms BBR-d6, Umbellatine-d6
Canonical SMILES [2H]C([2H])([2H])OC1=CC=C2C(C=[N+]3CCC4=C(C3=C2)C=C5OCOC5=C4)=C1OC([2H])([2H])[2H].[Cl-]
Formula C20H12D6NO4·Cl M.Wt 377.9
Solubility DMSO: slightly soluble,Methanol: slightly soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.6462 mL 13.231 mL 26.462 mL
5 mM 0.5292 mL 2.6462 mL 5.2924 mL
10 mM 0.2646 mL 1.3231 mL 2.6462 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Average Rating: 5 ★★★★★ (Based on Reviews and 28 reference(s) in Google Scholar.)

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