Berberine hydrochloride (Synonyms: BBR, Umbellatine, NSC 163088, NSC 646666) |
| Catalog No.GN10208 |
Berberine hydrochloride is an isoquinoline alkaloid derived from the Ranunculaceae medicinal plant Coptis chinensis. It has various pharmacological activities such as anti-tumor, anti-inflammatory, and hypoglycemic activities.
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Cas No.: 633-65-8
Sample solution is provided at 25 µL, 10mM.
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Berberine hydrochloride is a bioactive alkaloid of the isoquinoline class derived from the medicinal plant Coptis chinensis of the Ranunculaceae family, possessing a wide range of pharmacological functions with applications in cancer, inflammation, diabetes, depression, hypertension, and various infections. Berberine hydrochloride can induce oxidative DNA damage in cancer cells[1]. It is a dual inhibitor of topoisomerase I and II and a potential autophagy modulator [2]. Due to its activating effect on AMPK, it can improve insulin sensitivity and reduce blood sugar levels [3].
In vitro, berberine hydrochloride (1.25-160μM; 72 hours) exhibits potential inhibitory effects on the proliferation of four colorectal cancer cell lines, LoVo, HCT116, SW480, and HT-29, with IC50 values ranging from 40.8±4.1 μM (LoVo) to 98.6±2.9μM (HCT116) [1]. Berberine hydrochloride (40.0μM) can induce G2/M phase cell cycle arrest, with an increase in the G2/M cell population and a progressive decrease in the G1 cell population [1]. It induces a significant increase in apoptosis in MG63 cells in a concentration- and time-dependent manner [4].
In vivo, oral doses of berberine hydrochloride at 30 and 50 mg/kg/day inhibited the growth of human colorectal adenocarcinoma xenografts in nude mice by 33.1% and 45.3%,respectively[1].Berberine hydrochloride alleviates lipopolysaccharide-induced mouse enteritis by inhibiting the activation of the NF-κB signaling pathway [5].
References:
[1] Cai Y, et al. Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo. J Nat Med. 2014 Jan;68(1):53-62.
[2] Md. Reyad-ul F, et al. Berberine chloride (dual topoisomerase I and II inhibitor) modulate mitochondrial uncoupling protein (UCP1) in molecular docking and dynamic with in-vitro cytotoxic and mitochondrial ATP production.Journal of Biomolecular Structure and Dynamics. 2022 May;41: 1704-1714.
[3] J Yin, J Ye, W Jia, et al. Effects and mechanisms of berberine in diabetes treatment[J]. Acta Pharmaceutica Sinica B, 2012.
[4] Zhu Y , Ma N , Li H X ,et al.Berberine induces apoptosis and DNA damage in MG-63 human osteosarcoma cells[J].Molecular Medicine Reports, 2014, 10(4).
[5] Fu K , Lv X , Li W ,et al.Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice by suppressing activation of NF-kB signal pathway[J].INTERNATIONAL IMMUNOPHARMACOLOGY, 2015.
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