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β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human))

Catalog No.GC33693

β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)), a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

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β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)) Chemical Structure

Cas No.: 17908-57-5

Size Price Stock Qty
1mg
$166.00
In stock
5mg
$496.00
In stock
10mg
$836.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

β-Melanocyte Stimulating Hormone (MSH), human is a melanocortin (MC) receptor agonist.

β-Melanocyte Stimulating Hormone is a powerful anti-inflammatory agent which effect is brought by activation of the central MC3/MC4 receptors and thereby inhibits NO production by inhibiting the translocation of transcription factor NF-κB to the nuclei of the brain cells and decreasing iNOS expression[1]. β-Melanocyte Stimulating Hormone has significantly higher at human MC4-R transfected into CHO cells (Ki=11.4±0.4 nM) and MC4-R in rat hypothalamic homogenates (Ki=22.5±2.3 nM)[2].

β-Melanocyte Stimulating Hormone suppresses LPS-induced nuclear translocation of the transcription factor NF-κB, and inhibits the expression of inducible nitric oxide synthase, and the following nitric oxide overproduction in the brain[1].β-Melanocyte Stimulating Hormone is a key ligand at the MC4-R populations that regulate feeding, and that inhibition of tonic release of β-MSH is one mechanism contributing to hunger in under-feeding[2].

[1]. Muceniece R, et al. Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling. J Neuroimmunol. 2005 Dec;169(1-2):13-9. [2]. Harrold JA, et al. beta-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R? Peptides. 2003 Mar;24(3):397-405.

Chemical Properties

Cas No. 17908-57-5 SDF
Canonical SMILES Ala-Glu-Lys-Lys-Asp-Glu-Gly-Pro-Tyr-Arg-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp
Formula C118H174N34O35S M.Wt 2660.92
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.3758 mL 1.879 mL 3.7581 mL
5 mM 0.0752 mL 0.3758 mL 0.7516 mL
10 mM 0.0376 mL 0.1879 mL 0.3758 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 35 reference(s) in Google Scholar.)

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