Betamethasone-d5 (Synonyms: β-Methasone-d5, SCH 4831-d5) |
| Catalog No.GC52329 |
An internal standard for the quantification of betamethasone
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2244574-92-1
Sample solution is provided at 25 µL, 10mM.
;)
_1-7.$$$37316672@70.jpg');)
;)
;)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
;)
;)
;)
_1124-1138.$$$35908550@30.jpg');)
_766-780.$$$37100057@30.jpg');)
_418-432.$$$36893736@30.jpg');)
_240-255.$$$35108512@29.jpg');)
_533-545.$$$36543525@28.jpg');)
_264-276.$$$36600053@22.jpg');)
_2214998.$$$@0.jpg');)
Betamethasone-d5 is intended for use as an internal standard for the quantification of betamethasone by GC- or LC-MS. Betamethasone is a synthetic corticosteroid.1 In vivo, betamethasone (5 mg/kg) reduces bronchoalveolar lavage fluid (BALF) matrix metalloproteinase-2 (MMP-2) and MMP-9 activities, TNF-α levels, and neutrophil number in a mouse model of LPS-induced lung injury. Prenatal administration of betamethasone (0.1 mg/kg) improves neonatal lung function but decreases hippocampal and corpus callosum neuron density and induces motor function deficits in a rabbit model of late preterm birth.2 It also extends gestational length in a rat model of preterm labor induced by high mobility group protein B1 (HMGB1).3 Formulations containing betamethasone have been used in the treatment of inflammatory skin conditions and prenatally to promote fetal lung maturation.
1.Corbel, M., Lagente, V., ThÉret, N., et al.Comparative effects of betamethasone, cyclosporin and nedocromil sodium in acute pulmonary inflammation and metalloproteinase activities in bronchoalveolar lavage fluid from mice exposed to lipopolysaccharidePulm. Pharmacol. Ther.12(3)165-171(1999) 2.van der Merwe, J., van der Veeken, L., Inversetti, A., et al.Neurocognitive sequelae of antenatal corticosteroids in a late preterm rabbit modelAm. J. Obstet. Gynecol.226(6)850.e851-850.e821(2022) 3.Galaz, J., Romero, R., Arenas-Hernandez, M., et al.Betamethasone as a potential treatment for preterm birth associated with sterile intra-amniotic inflammation: A murine studyJ. Perinat. Med.49(7)897-906(2021)
| Cas No. | 2244574-92-1 | SDF | |
| Synonyms | β-Methasone-d5, SCH 4831-d5 | ||
| Canonical SMILES | O=C1C=C[C@@]2(C)C(C([2H])([2H])C[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@H](C)[C@]4(O)C(C([2H])([2H])O)=O)=C1[2H] | ||
| Formula | C22H24D5FO5 | M.Wt | 397.5 |
| Solubility | DMSO: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5157 mL | 12.5786 mL | 25.1572 mL |
| 5 mM | 0.5031 mL | 2.5157 mL | 5.0314 mL |
| 10 mM | 0.2516 mL | 1.2579 mL | 2.5157 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *