Home>>BI-9321 trihydrochloride
BI-9321 trihydrochloride Catalog No.GC39663

Size Price Stock Qty
10mM*1 mL in DMSO
$133.00
In stock
5mg
$121.00
In stock
10mg
$213.00
In stock
25mg
$417.00
In stock
50mg
$705.00
In stock
100mg
$1,112.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

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Chemical Properties

Cas No. 2387510-87-2 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES NCC1=CC(C)=C(C2=C(C3=CC=NC4=CC(F)=CC=C34)N(C)C=N2)C(C)=C1.[H]Cl.[H]Cl.[H]Cl
Formula C22H24Cl3FN4 M.Wt 469.81
Solubility DMSO: 250 mg/mL (532.13 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

BI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells[1].

[1]. BÖttcher J, et al. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat Chem Biol. 2019 Aug;15(8):822-829.