Big Endothelin-1 (1-38) (human) (trifluoroacetate salt) (Synonyms: BET-1 (1-38) (human)) |
| Catalog No.GC42930 |
Big endothelin-1 (BET-1) (1-38) is a peptide precursor of endothelin-1 produced by vascular smooth muscle and endothelium.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Big endothelin-1 (BET-1) (1-38) is a peptide precursor of endothelin-1 produced by vascular smooth muscle and endothelium. BET-1 is converted to endothelin-1 by endothelin-converting enzyme (ECE) and to endothelin-1 (1-31) by chymase. It is also converted to endothelin-1 (1-32) by matrix metalloproteinase-2 (MMP-2). BET-1 (50 pmol) induces vasoconstriction in isolated rat mesenteric arteries, an effect that is blocked by the MMP-2 antagonist TIMP-2. In vivo, BET-1 (0.1-10 nmol/kg, i.v.) dose-dependently increases blood pressure and bradycardia and leads to renal and hindquarter vasoconstriction in rats as well as abdominal constriction in mice (ED50 = 0.043 mg/kg), effects that are reversed or prevented by the ECE inhibitor phosphoramidon . It also induces mesenteric vasoconstriction in rats. Unlike endothelin-1, BET-1 (100 pmol/kg, i.v.) increases water and sodium excretion in rats independent of the endothelin A receptor.
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