BimS BH3 (51-76) (human) (trifluoroacetate salt) (Synonyms: DMRPEIWIAQELRRIGDEFNAYYARR-OH, Bims (51-76)) |
Catalog No.GC52355 |
A Bim-derived peptide
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
BimS BH3 (51-76) is a peptide that corresponds to amino acids 51-76 of the short splice variant of the pro-apoptotic protein Bim (BimS), which contains the Bcl-2 homology 3 (BH3) motif.1 It binds to myeloid cell leukemia-1 (Mcl-1), Bcl-xL, Bcl-2, and Bcl-W (IC50s = 18, 10, 7, and 18 nM, respectively). BimS BH3 (51-76) induces cytochrome c release from mitochondria derived from bcl-x-/- mouse embryonic fibroblasts (MEFs).
1.Lee, E.F., Fedorova, A., Zobel, K., et al.Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteinsJ. Biol. Chem.284(45)31315-31326(2009)
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