Home>>Biotin-PEG4-amino-t-Bu-DADPS-C6-azide
Biotin-PEG4-amino-t-Bu-DADPS-C6-azide Catalog No.GC60646

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25mg
$556.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1260247-50-4 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C(NCC(C)(O[Si](C1=CC=CC=C1)(OCCCCCCN=[N+]=[N-])C2=CC=CC=C2)C)CCOCCOCCOCCOCCNC(CCCC[C@@H]3SC[C@]([C@]3([H])N4)([H])NC4=O)=O
Formula C43H67N7O9SSi M.Wt 886.18
Solubility DMSO: 100 mg/mL (112.84 mM) Storage -20°C, protect from light
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562