BMS-1001 hydrochloride |
| Catalog No.GC38740 |
BMS-1001 hydrochloride is an orally active human PD-L1/PD-1 immune checkpoint inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2113650-04-5
Sample solution is provided at 25 µL, 10mM.
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BMS-1001 hydrochloride is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 hydrochloride exhibits low-toxicity in cells[1].
BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 presents low toxicity towards tested cell lines and block the interaction of soluble PD-L1 with the cell surface-expressed PD-1. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes[1].
[1]. Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181.
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