Bradykinin Fragment (1-5) (trifluoroacetate salt) (Synonyms: Arg-Pro-Pro-Gly-Phe, BK1-5, RPPGF) |
| Catalog No.GC52424 |
A metabolite of bradykinin
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Bradykinin fragment (1-5) is a metabolite of the endogenous vasodilator bradykinin .1 It is formed from bradykinin by angiotensin-converting enzyme (ACE). Bradykinin fragment (1-5) (100 nM) increases the production of nitric oxide (NO) in neonatal rat cardiomyocytes.2 It inhibits α-thrombin-induced platelet aggregation of washed isolated platelets (IC50 = 0.5 mM).3 Bradykinin fragment (1-5) prevents decreases in mean arterial blood pressure and heart rate and increases survival in a rat model of LPS-induced septicemia.4
1.Bujak-Gi?ycka, B., Olszanecki, R., Madej, J., et al.Metabolism of bradykinin in aorta of hypertensive ratsActa Biochim. Pol.58(2)199-202(2011) 2.Souza-Silva, I.M., de Paula, C.A., Bolais-Amos, L., et al.Peptide fragments of bradykinin show unexpected biological activity not mediated by B1 or B2 receptorsBr. J. Pharmacol.179(12)3061-3077(2022) 3.Hasan, A.A.K., Amenta, S., and Schmaier, A.H.Bradykinin and its metabolite, Arg-Pro-Pro-Gly-Phe, are selective inhibitors of α-thrombin-induced platelet activationCirculation94(3)517-528(1996) 4.Morinelli, T.A., Webb, J.G., Jaffa, A.A., et al.A metabolic fragment of bradykinin, Arg-Pro-Pro-Gly-Phe, protects against the deleterious effects of lipopolysaccharide in ratsJ. Pharmacol. Exp. Ther.296(1)71-76(2001)
| Cas No. | SDF | ||
| Synonyms | Arg-Pro-Pro-Gly-Phe, BK1-5, RPPGF | ||
| Canonical SMILES | N=C(N)NCCC[C@H](N)C(N1[C@H](C(N2[C@H](C(NCC(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)=O)CCC2)=O)CCC1)=O.OC(C(F)(F)F)=O | ||
| Formula | C27H40N8O6 ? XCF3COOH | M.Wt | 572.7 |
| Solubility | DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 5 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.7461 mL | 8.7306 mL | 17.4611 mL |
| 5 mM | 0.3492 mL | 1.7461 mL | 3.4922 mL |
| 10 mM | 0.1746 mL | 0.8731 mL | 1.7461 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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