Brequinar sodium (Synonyms: DuP-785, NSC 368390) |
| Catalog No.GC50377 |
Potent and selective DHODH inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 96201-88-6
Sample solution is provided at 25 µL, 10mM.
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Potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Causes depletion of pyrimidine nucleotides. Exhibits minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines (ED50 = ~ 1 μM. Note uridine concentration effects ED50 value). Causes differentiation and depletion of leukemia-initiating cells in vivo. Antimetabolite.
Arteaga (1989) Phase I clinical and pharmacokinetic trial of Brequinar sodium (DuP 785; NSC 368390). Cancer Res. 49 4648 PMID:2743343 |Sykes et al (2016) Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia. Cell 167 171 PMID:27641501 |Peters et al (1987) Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390). Invest.New Drugs 5 235 PMID:2822596
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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