Bromadiolone (Synonyms: Bromatrol, Broprodifacoum) |
| Catalog No.GC45620 |
An anticoagulant rodenticide
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 28772-56-7
Sample solution is provided at 25 µL, 10mM.
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Bromadiolone is a second generation anticoagulant rodenticide and 4-hydroxycoumarin derivative.1,2 It is an inhibitor of vitamin K epoxide reductase (VKOR) that inhibits blood clotting. It inhibits human VKOR complex subunit 1 (VKORC1) with an IC50 value of 1.6 nM in a cell-based assay.3 Bromadiolone is toxic to rodents, including mice (LD50 = 1.75 mg/kg) and rats (LD50s = 1.05 and 1.83 mg/kg for males and females, respectively).4,5 It does not significantly affect breeding performance in mice when administered at a dose of up to 70% of the LD50 value.6 Resistance to bromadiolone is conferred by mutations to the VKOR gene, Vkorc1.7 Formulations containing bromadiolone have been used in the control of rodent pest populations.
|1. Watt, B.E., Proudfoot, A.T., Bradberry, S.M., et al. Anticoagulant rodenticides. Toxicol. Rev. 24(4), 259-269 (2005).|2. Misenheimer, T.M., Lund, M., Baker, A.E.M., et al. Biochemical basis of warfarin and bromadiolone resistance in the house mouse, Mus musculus domesticus. Biochem. Pharmacol. 47(4), 673-678 (1994).|3. Czogalla, K.J., Liphardt, K., H•ning, K., et al. VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites. Blood Adv. 2(6), 691-702 (2018).|4. Vandenbroucke, V., Bousquet-Melou, A., De Backer, P., et al. Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration. J. Vet. Pharmacol. Ther. 31(5), 437-445 (2008).|5. Garg, N., and Singla, N. Toxicity of second generation anticoagulant bromadiolone against Rattus Rattus: individual and sex specific variations. Cibtech J. Zoo. 3(2), 43-48 (2014).|6. Twigg, L.E., and Kay, B.J. The effect of sub-lethal doses of bromadiolone on the breeding performance of house mice (Mus domesticus). Comp. Biochem. Physiol. 110(1), 77-82 (1995).|7. Pelz, H.-J., Rost, S., HÜnerberg, M., et al. The genetic basis of resistance to anticoagulants in rodents. Genetics 170(4), 1839-1847 (2005).
| Cas No. | 28772-56-7 | SDF | |
| Synonyms | Bromatrol, Broprodifacoum | ||
| Canonical SMILES | BrC1=CC=C(C2=CC=C(C(O)CC(C3=CC=CC=C3)C4=C(O)C5=C(C=CC=C5)OC4=O)C=C2)C=C1 | ||
| Formula | C30H23BrO4 | M.Wt | 527.4 |
| Solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.8961 mL | 9.4805 mL | 18.9609 mL |
| 5 mM | 0.3792 mL | 1.8961 mL | 3.7922 mL |
| 10 mM | 0.1896 mL | 0.948 mL | 1.8961 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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