BSJ-03-204 |
| Catalog No.GC50615 |
Selective Cdk4/6 degrader
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2349356-09-6
Sample solution is provided at 25 µL, 10mM.
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Selective Cdk4/6 degrader. Displays cereblon-dependent degradation with no effect on IKZF1/3 in Molt4 cells. Induces degradation of Cdk4/6 and G1 cell cycle arrest, and inhibits cell proliferation in a mantle cell lymphoma (MCL) cell line.
Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID:30802347
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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