C22 1-Deoxyceramide (m18:1(14Z)/22:0) (Synonyms: C22 Ceramide (m18:1/22:0), Cer(m18:1/22:0), N-docosanoyl-1-deoxy-4,5-dihydro-14Z-Sphingosine) |
| Catalog No.GC45663 |
A long-chain atypical ceramide
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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C22 1-deoxyceramide (m18:1(14Z)/22:0) is a long-chain atypical ceramide containing a 1-deoxysphingosine (m18:1(14Z)) backbone with a cis double bond at the 14-15 position rather than a trans double bond at the 4-5 position. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2
|1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemical structure of native 1-deoxysphingosine. J. Lipid Res. 57(7), 1194-1203 (2016).|2. Alecu, I., Othman, A., Penno, A., et al. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway. J. Lipid Res. 58(1), 60-71 (2017).
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