Calcineurin Autoinhibitory Peptide

Name: Calcineurin Autoinhibitory Peptide
Brand: GlpBio
SKU: GC12743
Availability: InStock
Rating: 5 (30 reviews)

Catalog No.GC12743

Selective inhibitor of Ca²⁺-calmodulin-dependent protein phosphatase (calcineurin) (IC₅₀ ~ 10 mM).

Products are for research use only. Not for human use. We do not sell to patients.

Calcineurin Autoinhibitory Peptide Chemical Structure

Cas No.: 148067-21-4

Size

Price

Stock

Qty

1mg

$189.00

In stock

Tel：(909) 407-4943 Email: sales@glpbio.com

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

View current batch:

Purity: >98.00%

Selective inhibitor of Ca²⁺-calmodulin-dependent protein phosphatase (calcineurin) (IC₅₀ ~ 10 mM). Does not inhibit PP1, PP2A or CaM kinase II (IC₅₀ > 100 mM).

Cas No.	148067-21-4	SDF
Chemical Name	(4S,5Z,7S,8Z,10S,11Z,13S,14Z,16S,17Z,19S,20Z,23Z,25S,26Z,28S,29Z,31S,32Z,34S)-34-((Z)-((S)-2-((Z)-((S)-2-((Z)-((2S,3R)-2-((Z)-((2S,3S)-2-amino-1-hydroxy-3-methylpentylidene)amino)-1,3-dihydroxybutylidene)amino)-1,3-dihydroxypropylidene)amino)-1-hydroxy-3-
Canonical SMILES	CC[C@]([C@@](N)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(N1CCC[C@@]1([H
Formula	C₁₂₄H₂₀₅N₃₉O₃₉S₂	M.Wt	2930.32
Solubility	Soluble to 1 mg/ml in Water	Storage	Desiccate at -20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
		1 mg	5 mg	10 mg
	1 mM	0.3413 mL	1.7063 mL	3.4126 mL
	5 mM	0.0683 mL	0.3413 mL	0.6825 mL
	10 mM	0.0341 mL	0.1706 mL	0.3413 mL

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal:μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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Calcineurin Autoinhibitory Peptide

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