Carbazochrome (Synonyms: Adrenochrome Monosemicarbazone, Adrenochrome Semicarbazone, NSC 73742) |
| Catalog No.GC60670 |
A hemostatic agent
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 69-81-8
Sample solution is provided at 25 µL, 10mM.
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Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent[1].
Carbazochrome (0.1-10 µM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3 in a concentration-dependent manner[1].Carbazochrome (0.1-1 µM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances[1].
Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats[2]. Animal Model: Male Sprague-Dawley rats weighing 180-230 g[2]
[1]. Toshiaki Sendo, et al. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80. [2]. Toshiaki Sendo, et al. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol. 2002 Aug 23;450(2):203-8.
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