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Carbidopa-d3 (hydrate) (Synonyms: (S)-(-)-Carbidopa-d3 monohydrate)

Catalog No.GC49396

An internal standard for the quantification of carbidopa

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Carbidopa-d3 (hydrate) Chemical Structure

Cas No.: 1276197-58-0

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1 mg
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5 mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Carbidopa-d3 is intended for use as an internal standard for the quantification of carbidopa by GC- or LC-MS. Carbidopa is a peripherally restricted inhibitor of dopamine decarboxylase, the enzyme that converts L-DOPA to dopamine.1 Administration of carbidopa (100 mg/kg) prior to administration of L-DOPA in dogs increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66%.2 Carbidopa also binds to and potentiates the activity of the aryl hydrocarbon receptor (AhR).3 It inhibits the proliferation of pancreatic cancer cells in vitro and tumor growth in vivo. Formulations containing carbidopa are used in combination with L-DOPA in the treatment of Parkinson’s disease to increase the amount of dopamine in the brain and reduce peripheral side effects associated with L-DOPA administration.

1.Clark, W.G., Oldendorf, W.H., and Dewhurst, W.G.Blood-brain barrier to carbidopa (MK-486) and Ro 4-4602, peripheral dopa decarboxylase inhibitorsJ. Pharm. Pharmacol.25(5)416-418(1973) 2.Deleu, D., Sarre, S., Ebinger, G., et al.The effect of carbidopa on the pharmacokinetics and metabolism of intravenously administered levodopa in blood plasma and skeletal muscleNaunyn Schmiedebergs Arch. Pharmacol.348(6)576-581(1993) 3.Ogura, J., Miyauchi, S., Shimono, K., et al.Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapyBiochem J.474(20)3391-3402(2017)

Chemical Properties

Cas No. 1276197-58-0 SDF
Synonyms (S)-(-)-Carbidopa-d3 monohydrate
Canonical SMILES OC(C([2H])=C1C[C@@](NN)(C)C(O)=O)=C(C([2H])=C1[2H])O.O
Formula C10H11D3N2O4·H2O M.Wt 247.3
Solubility DMSO: slightly soluble,Methanol: slightly soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.0437 mL 20.2184 mL 40.4367 mL
5 mM 0.8087 mL 4.0437 mL 8.0873 mL
10 mM 0.4044 mL 2.0218 mL 4.0437 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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