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Phosphatase

Products for  Phosphatase

  1. Cat.No. Product Name Information
  2. GC41774 1,2,3-Trimyristoyl-rac-glycerol 1,2,3-Trimyristoyl-rac-glycerol, an active molluscicidal component ofMyristica fragransHoutt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue ofLymnaea acuminata. 1,2,3-Trimyristoyl-rac-glycerol  Chemical Structure
  3. GC25005 1-Naphthyl phosphate potassium salt 1-Naphthyl phosphate potassium salt (α-Naphthyl acid phosphate monopotassium salt) is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases. 1-Naphthyl phosphate potassium salt  Chemical Structure
  4. GC60019 3,5-Difluoro-L-tyrosine 3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine  Chemical Structure
  5. GC65394 7-BIA 7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM. 7-BIA  Chemical Structure
  6. GC63921 ABBV-CLS-484 ABBV-CLS-484 is a potent PTPN1 or PTPN2 inhibitor with a sub-nanomolar activity. ABBV-CLS-484  Chemical Structure
  7. GC65098 ARL67156 triethylamine ARL67156 (FPL 67156) triethylamine is a selective ecto-ATPase inhibitor. ARL67156 triethylamine  Chemical Structure
  8. GC65097 ARL67156 trisodium hydrate ARL67156 (FPL 67156) trisodium hydrate is a selective ecto-ATPase inhibitor. ARL67156 trisodium hydrate  Chemical Structure
  9. GC60600 ARL67156 trisodium salt hydrate ARL67156 trisodium salt hydrate  Chemical Structure
  10. GC46093 Azadirachtin B An azadirachtin with diverse biological activities Azadirachtin B  Chemical Structure
  11. GC65025 BCI hydrochloride BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride  Chemical Structure
  12. GC60647 Bis(maltolato)oxovanadium(IV) Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV)  Chemical Structure
  13. GC63788 BN82002 hydrochloride BN82002 hydrochloride is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 hydrochloride inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 ?M, respectively. BN82002 hydrochloride displays ~20-fold greater selectivity over CD45 tyrosine phosphatase. BN82002 hydrochloride  Chemical Structure
  14. GC42969 bpV(phen) (potassium hydrate) bpV(phen) (potassium hydrate), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) (potassium hydrate)  Chemical Structure
  15. GC64161 Calcium glycerophosphate Calcium glycerophosphate is an inhibitor of intestinal alkaline phosphatase F3. Calcium glycerophosphate  Chemical Structure
  16. GC62892 CDC25B-IN-2 CDC25B-IN-2 is a potent cdc25B inhibitor. CDC25B-IN-2  Chemical Structure
  17. GC60706 Chrysophanol triglucoside Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC50s of 80.17 and 197.06 ?M, respectively. Chrysophanol triglucoside  Chemical Structure
  18. GC62909 CPT-157633 CPT-157633, a difluoro-phosphonomethyl phenylalanine derivative, and is a PTP1B inhibitor. CPT-157633  Chemical Structure
  19. GC39295 DJ001 DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC50 of 1.43 μM. DJ001  Chemical Structure
  20. GC62943 DPM-1001 trihydrochloride DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 trihydrochloride  Chemical Structure
  21. GC65260 EDP-305 EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells). EDP-305  Chemical Structure
  22. GC59040 FAM alkyne, 5-isomer FAM alkyne, 5-isomer is a high selective and sensitive fluorescent biosensor for alkaline phosphatase (ALP). FAM alkyne, 5-isomer  Chemical Structure
  23. GC46147 Fenvalerate A pyrethroid ester insecticide and acaricide Fenvalerate  Chemical Structure
  24. GC63327 Fenvalerate-d5 Fenvalerate-d5  Chemical Structure
  25. GC64376 GDC-1971 GDC-1971 (compound 199) is a SHP2 inhibitor. GDC-1971  Chemical Structure
  26. GC67938 Guaiacin Guaiacin  Chemical Structure
  27. GC62345 IACS-13909 IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers. IACS-13909  Chemical Structure
  28. GC62677 Icerguastat Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat  Chemical Structure
  29. GC44008 KLH45 KLH45 is an inhibitor of the phospholipase DDHD domain containing 2 (DDHD2; IC50 = 1.3 nM). KLH45  Chemical Structure
  30. GC61578 L-690330 hydrate L-690330 hydrate is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 hydrate  Chemical Structure
  31. GC19511 L-Ascorbic Acid 2-phosphate (magnesium salt) L-Ascorbic Acid 2-phosphate (magnesium salt) (2-Phospho-L-ascorbic acid magnesium) is along-actingvitaminCderivativethat can stimulate collagen formation and expression. L-Ascorbic Acid 2-phosphate (magnesium salt)  Chemical Structure
  32. GC64338 LYP-IN-1 LYP-IN-1 is a potent, selective and specific LYP inhibitor with a Ki and an IC50 of 110 nM and 0.259 μM, respectively. LYP-IN-1  Chemical Structure
  33. GC67798 MLS-0437605 MLS-0437605  Chemical Structure
  34. GC61408 MLS000544460 MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity. MLS000544460  Chemical Structure
  35. GC64031 MP07-66 MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to PP2A reactivation. MP07-66  Chemical Structure
  36. GC64030 MY10 MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10  Chemical Structure
  37. GC69515 MY33-3

    MY33-3 is an effective and selective inhibitor of protein tyrosine phosphatase RPTPβ/ζ, with an IC50 value of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate neuroinflammation and cognitive dysfunction caused by Sevoflurane.

    MY33-3  Chemical Structure
  38. GC64605 MY33-3 hydrochloride MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 hydrochloride  Chemical Structure
  39. GC65157 Naphthol AS-BR Naphthol AS-BR is a substrate for the histochemical demonstration of acid and alkaline phosphatase. Naphthol AS-BR  Chemical Structure
  40. GC61621 NAZ2329 NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 ?M for hPTPRZ1) and PTPRG (IC50=4.8 ?M for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC50 of 1.1 ?M) than the whole intracellular (D1?+?D2) fragment (IC50 of 7.5 ?M). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties. NAZ2329  Chemical Structure
  41. GC61403 NCGC00249987 NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells. NCGC00249987  Chemical Structure
  42. GC62286 NCGC00378430 NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor. NCGC00378430 partially reverses transcriptional and metabolic profiles mediated by SIX1 overexpression and reverses SIX1-induced TGF-β signaling and epithelial-mesenchymal transition (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in a mouse model. NCGC00378430  Chemical Structure
  43. GC65542 NSC-87877 disodium NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26). NSC-87877 disodium  Chemical Structure
  44. GC61609 PHPS1 sodium PHPS1 sodium is a potent and selective Shp2 inhibitor with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively. PHPS1 sodium  Chemical Structure
  45. GC69736 PRL-3 Inhibitor 2

    PRL-3 Inhibitor 2 (compound 2) is an effective inhibitor of PRL-3, with an IC50 value of 28.1 μM.

    PRL-3 Inhibitor 2  Chemical Structure
  46. GC39066 Prunin A flavonoid glycoside with diverse biological activities Prunin  Chemical Structure
  47. GC64556 PTP1B-IN-15 PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15  Chemical Structure
  48. GC63705 PTP1B-IN-3 diammonium PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 diammonium  Chemical Structure
  49. GC62687 Razuprotafib Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib  Chemical Structure
  50. GC63487 RMC-4630 RMC-4630 (SHP2-IN-7) is an SHP2 inhibitor extracted from patent WO2018013597. RMC-4630  Chemical Structure
  51. GC61524 SC-43 SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects. SC-43  Chemical Structure
  52. GC65308 SHIP2-IN-1 SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 ?M. SHIP2-IN-1  Chemical Structure
  53. GC25930 SHP099 HCl SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1. SHP099 HCl  Chemical Structure
  54. GC62570 SHP2-IN-6 hydrochloride SHP2-IN-6 hydrochloride is a potent SHP2 inhibitor with an IC50 of 25.8 nM. SHP2-IN-6 hydrochloride is extracted from patent WO2017211303A1, compound 7. SHP2-IN-6 hydrochloride  Chemical Structure
  55. GC63190 SHP389 SHP389 is an allosteric SHP2 inhibitor, with an IC50 of 36 nM for both SHP2 and p-ERK. SHP389  Chemical Structure
  56. GC65533 SHP394 SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM. SHP394  Chemical Structure
  57. GC60337 SHP836 SHP836 is a SHP2 allosteric inhibitor, with an IC50 of 12 μM for the full length SHP2. SHP836  Chemical Structure
  58. GC69932 SPAA-52

    SPAA-52 is a low molecular weight protein tyrosine phosphatase (LMW-PTP) inhibitor with oral activity, competitive and reversible properties (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used for research on diabetes.

    SPAA-52  Chemical Structure
  59. GC62191 TD52 TD52, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity. TD52  Chemical Structure
  60. GC64936 TD52 dihydrochloride TD52 dihydrochloride, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity. TD52 dihydrochloride  Chemical Structure
  61. GC60364 Thienopyridone Thienopyridone is a potent and selective phosphatase of regenerating liver (PRL) phosphatase inhibitor with IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively. Thienopyridone shows minimal effects on other phosphatases. Thienopyridone induces p130Cas cleavage and apoptosis and has anticancer effects. Thienopyridone  Chemical Structure
  62. GC61347 TRC-766 TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766  Chemical Structure
  63. GC70095 Uralenol

    Uralenol is a natural PTP1B inhibitor (IC50=21.5 μM) derived from Broussonetia papyrifera. In many cellular and biochemical studies, PTP1B has been shown to play a major role in the dephosphorylation of insulin receptors.

    Uralenol  Chemical Structure
  64. GC18533 ZLDI-8

    Temiverine hydrochloride is a synthesized drug that is expected to have anticholinergic action.

    ZLDI-8  Chemical Structure

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