(+)-Sparteine (Synonyms: Pachycarpin, Pachycarpine) |
| Catalog No.GC34959 |
(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 492-08-0
Sample solution is provided at 25 µL, 10mM.
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(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.
(+)-Sparteine (2 μM) reduces the ACh-induced current caused by activation of nicotinic AChRs in a voltage-independent manner. (+)-Sparteine (5, 10 μM) reduces the amplitude of the excitatory postsynaptic current (EPSC) and the time constant of the EPSC decay[1].
References:
[1]. Voitenko S, et al. Effect of (+)-sparteine on nicotinic acetylcholine receptors in the neurons of rat superior cervical ganglion. Mol Pharmacol. 1991 Aug;40(2):180-5.
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