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Sulfisoxazole (Synonyms: NSC 13120, NSC 33807, NSC 38588, NSC 683536, Sulfafurazole)

Catalog No.GC12231

selective ETA endothelin receptor antagonist

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Sulfisoxazole Chemical Structure

Cas No.: 127-69-5

Size Price Stock Qty
10mM (in 1mL DMSO)
$38.00
In stock
50mg
$53.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Sulfisoxazole, an endothelin receptor antagonist, is a sulfonamide antibacterial with an oxazole substituent.Target: Antibacterial; Endothelin ReceptorThe sulfanilamide antibacterial agent sulfisoxazole was found to be a good endothelin receptor antagonist (IC50's of 0.60 microM and 22 microM for the ETA and ETB receptors, respectively) [1]. Sulfisoxazole is used to treat or prevent infections in many different parts of the body. It belongs to the group of medicines known as sulfonamide antibiotics. It works by preventing the growth of bacteria [2].

References:
[1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.
[2]. http://www.mayoclinic.org/drugs-supplements/sulfisoxazole-oral-route/description/drg-20072998

Chemical Properties

Cas No. 127-69-5 SDF
Synonyms NSC 13120, NSC 33807, NSC 38588, NSC 683536, Sulfafurazole
Chemical Name 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
Canonical SMILES CC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)N
Formula C11H13N3O3S M.Wt 267.3
Solubility ≥ 10.65mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.7411 mL 18.7056 mL 37.4111 mL
5 mM 0.7482 mL 3.7411 mL 7.4822 mL
10 mM 0.3741 mL 1.8706 mL 3.7411 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 15 reference(s) in Google Scholar.)

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