D-Pantothenic acid |
Catalog No.GC17311 |
water-soluble vitamin
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 79-83-4
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
D-Pantothenic acid (vitamin B5) is a water-soluble vitamin and is an essential nutrient to synthesize coenzyme-A, fats, proteins and carbohydrates.
D-Pantothenic acid is a water-soluble vitamin. In rabbits, pentothenate (20 mg/kg) significantly increased aponeurosis strength after surgery and improved the strength of the skin. Also, pentothenate significantly increased the fibroblast content of the scar during the fibroblast proliferation phase [1]. Pantothenic acid deficiency increased occurrence of hypertension due to adrenal regeneration [2]. In rabbits, cerebellar and forebrain slices were able to accumulate and phosphorylate pantothenic acid. However, medium-chain fatty acids, probenecid and ouabain inhibited pantothenic acid accumulation by forebrain slices and inhibited conversion to CoA [3]. In ICR mice, pantothenic acid significantly reduced valproic acid (VPA)-induced exencephaly, which suggested that pantothenic acid inhibited neural tube defects induced by VPA [4].
References:
[1]. Aprahamian M, Dentinger A, Stock-Damgé C, et al. Effects of supplemental pantothenic acid on wound healing: experimental study in rabbit. Am J Clin Nutr, 1985, 41(3): 578-589.
[2]. Schwabedal PE, Pietrzik K, Wittkowski W. Pantothenic acid deficiency as a factor contributing to the development of hypertension. Cardiology, 1985, 72 Suppl 1: 187-189.
[3]. Spector R. Development and characterization of pantothenic acid transport in brain. J Neurochem, 1986, 47(2): 563-568.
[4]. Sato M, Shirota M, Nagao T. Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I). Teratology, 1995, 52(3): 143-148.
Cas No. | 79-83-4 | SDF | |
Chemical Name | 3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acid | ||
Canonical SMILES | CC(C)(CO)C(C(=O)NCCC(=O)O)O | ||
Formula | C9H17NO5 | M.Wt | 219.23954 |
Solubility | ≥ 11.15mg/mL in DMSO with gentle warming | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 4.5612 mL | 22.8061 mL | 45.6122 mL |
5 mM | 0.9122 mL | 4.5612 mL | 9.1224 mL |
10 mM | 0.4561 mL | 2.2806 mL | 4.5612 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
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