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Pimprinine (Synonyms: NSC 80793)

Catalog No.GC18707

Pimprinine is an alkaloid originally isolated from Streptomyces that has diverse biological activities, including anticonvulsant, antiplatelet, and antimicrobial properties.

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Pimprinine Chemical Structure

Cas No.: 13640-26-1

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1mg
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5mg
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Sample solution is provided at 25 µL, 10mM.

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Background

Pimprinine is an alkaloid originally isolated from Streptomyces that has diverse biological activities, including anticonvulsant, antiplatelet, and antimicrobial properties. It inhibits deamination of serotonin by monoamine oxidase (MAO; IC50 = 48 μM). Pimprinine (80 mg/kg) increases the minimum and maximum electroshock seizure thresholds in mice. In a mouse model of tremorine-induced tremors, it increases the latency to tremor onset, as well as reduces the intensity and duration of tremors and the analgesic activity of tremorine when administered at a dose of 80 mg/kg. Pimprinine inhibits aggregation of rabbit platelets induced by arachidonic acid or collagen (IC50s = 3 and 25 μg/ml, respectively) and arachidonic acid-induced thromboxane A2 (TXA2) synthesis in rabbit platelets in vitro (IC50 = 6 μg/ml). It also inhibits the growth of M. tuberculosis, P. varioti, C. albicans, and S. lutea in vitro (MICs = 25, 1, 1.5, and 2.5 μg/ml, respectively).

References:
[1].Takeuchi, T., Ogawa, K., Iinuma, H., et al. Monoamine oxidase inhibitors isolated from fermented broths J. Antibiot. (Tokyo) 26(3), 162-167 (1973).
[2].Naik, S.R., Harindran, J., and Varde, A.B. Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: Fermentation, isolation and pharmacological activity J. Biotechnol. 88(1), 1-10 (2001).
[3].Umehara, K., Yoshida, K., Okamoto, M., et al. Studies on new antiplatelet agents, WS-30581 A and B J. Antibiot. (Tokyo) 37(10), 1153-1160 (1984).
[4].Intaraudom, C., Rachtawee, P., Suvannakad, R., et al. Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924 Tetrahedron 67(39), 7593-7597 (2011).

Chemical Properties

Cas No. 13640-26-1 SDF
Synonyms NSC 80793
Chemical Name 3-(2-methyl-5-oxazolyl)-1H-indole
Canonical SMILES CC(O1)=NC=C1C2=CNC3=CC=CC=C32
Formula C12H10N2O M.Wt 198.2
Solubility DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 5.0454 mL 25.227 mL 50.4541 mL
5 mM 1.0091 mL 5.0454 mL 10.0908 mL
10 mM 0.5045 mL 2.5227 mL 5.0454 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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