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Home >> Search results for: 'HDAC'
  1. Cat.No. Product Name Information
  2. GC33317 HDAC6-IN-1 HDAC6-IN-1 is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively. HDAC6-IN-1 Chemical Structure
  3. GC64959 JAK/HDAC-IN-1 JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively. JAK/HDAC-IN-1 Chemical Structure
  4. GC65460 HDACs/mTOR Inhibitor 1 HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1 Chemical Structure
  5. GC19189 HDAC8-IN-1 HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM. HDAC8-IN-1 Chemical Structure
  6. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent

     AR-42 (OSU-HDAC42) Chemical Structure
  7. GC19190 HDAC-IN-4 HDAC-IN-4 is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-4 has no activity against HDAC class II. HDAC-IN-4 has antitumor activity. HDAC-IN-4 Chemical Structure
  8. GC66052 HDAC-IN-40 HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects. HDAC-IN-40 Chemical Structure
  9. GC41085 HDAC6 Inhibitor HDAC6 Inhibitor is a potent and selective HDAC6 inhibitor (IC50=36 nM). HDAC6 Inhibitor weakly inhibits other HDAC isoforms. HDAC6 Inhibitor inhibits acyl-tubulin accumulation in cells with an IC50 value of 210 nM. HDAC6 Inhibitor Chemical Structure
  10. GC62434 LSD1/HDAC6-IN-1 LSD1/HDAC6-IN-1 is an orally active dual inhibitor of lysine specific demethylase 1(LSD1)/Histone deacetylase 6 (HDAC6), with anti-tumor activity. LSD1/HDAC6-IN-1 can be used for the research of multiple myeloma (MM). LSD1/HDAC6-IN-1 Chemical Structure
  11. GC36905 PI3K/HDAC-IN-1 PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively. PI3K/HDAC-IN-1 Chemical Structure
  12. GC41495 HDAC3 Inhibitor HDAC3 Inhibitor (compound 5) is a potent and selective HDAC3 inhibitor, with an IC50 of 5.96 nM. HDAC3 Inhibitor Chemical Structure
  13. GC12019 TCS HDAC6 20b TCS HDAC6 20b is a HDAC6-selective inhibitor. TCS HDAC6 20b blocks the growth of estrogen receptor α-positive breast cancer MCF-7 cells. TCS HDAC6 20b Chemical Structure
  14. GC33395 HDAC-IN-5 HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor. HDAC-IN-5 Chemical Structure
  15. gc21178 HDAC-IN-4 d4 HDAC-IN-4 d4 Chemical Structure
  16. GC49693 HDAC5 (human, recombinant) Active, pure human recombinant enzyme HDAC5 (human, recombinant) Chemical Structure
  17. GC19406 TH34

    TH34 is a potent HDAC6/8/10 inhibitor

     TH34 Chemical Structure
  18. GC13591 TC-H 106 TC-H 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs. TC-H 106 Chemical Structure
  19. GC13408 CI994 (Tacedinaline) CI994 (Tacedinaline) (N-acetyldinaline) is an inhibitor of the histone deacetylase (HDAC) with IC50s of 0.9, 0.9, 1.2 μM for recombinant HDAC 1, 2 and 3 respectively. CI994 (Tacedinaline) Chemical Structure
  20. GC17390 Vorinostat (SAHA, MK0683) Vorinostat (SAHA, MK0683) (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC6 and HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat (SAHA, MK0683) Chemical Structure
  21. GC15526 Trichostatin A (TSA) Trichostatin A (TSA) (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC. Trichostatin A (TSA) Chemical Structure
  22. GA20566 Ac-Gly-Ala-Lys(Ac)-AMC Ac-GAK(Ac)-AMC, fluorogenic substrate for measuring histone deacetylase class I (HDAC 1, 2, 3, and 8) and class II (HDAC 6 and 10) activity in a protease-coupled assay. HDAC-catalyzed deacetylation of Lys yields Ac-GAK-AMC (I-1980). Ac-Gly-Ala-Lys(Ac)-AMC Chemical Structure
  23. GC64684 SB-429201 SB-429201 is a potent and selective HDAC1 (IC50~1.5 μM). SB-429201 displays at least a 20-fold preference for HDAC1 inhibition over HDAC3 and HDAC8. SB-429201 Chemical Structure
  24. GC62461 FNDR-20123 FNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 Chemical Structure
  25. GA21064 Boc-Lys(Tfa)-AMC Fluorogenic substrate for assaying histone deacetylase (HDAC) 4, 5 and 7 activity in a protease-coupled assay. Suitable substrate for HDAC 8. The deacylated product Boc-Lys-AMC corresponds to I-1880. Boc-Lys(Tfa)-AMC Chemical Structure
  26. GA20481 Ac-Arg-Gly-Lys(Ac)-AMC Ac-RGK(Ac)-AMC, fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin. Ac-Arg-Gly-Lys(Ac)-AMC Chemical Structure
  27. GC34629 J22352 J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1. J22352 Chemical Structure
  28. GC30526 ACY-957 ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 Chemical Structure
  29. GC25552 KT-531 KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms. KT-531 Chemical Structure
  30. GC25139 Biphenyl-4-sulfonyl chloride Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation. Biphenyl-4-sulfonyl chloride Chemical Structure
  31. GC66055 5-Phenylpentan-2-one 5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research. 5-Phenylpentan-2-one Chemical Structure
  32. GC65965 MPT0E028 MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity. MPT0E028 Chemical Structure
  33. GC52166 NN-390 NN-390 is a potent and selective HDAC6 inhibitor, with an IC50 of 9.8 nM. NN-390 penetrates the blood-brain barrier (BBB). NN-390 shows study potential in metastatic Group 3 MB (medulloblastoma). NN-390 Chemical Structure
  34. GC65426 CM-675 CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 Chemical Structure
  35. GC65330 AES-135 AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM. AES-135 Chemical Structure
  36. GC65254 MC4355 MC4355 is a dual inhibitor of EZH2 and histone deacetylase (HDAC). MC4355 Chemical Structure
  37. GC65206 FT895 FT895 is a potent and selective HDAC11 inhibitor with an IC50 of 3 nM. FT895 Chemical Structure
  38. GC64968 SW-100 SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 Chemical Structure
  39. GC64942 CHDI-390576 CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. CHDI-390576 Chemical Structure
  40. GC64729 MPT0B390 MPT0B390 is an arylsulfonamide-based derivative with potent HDAC inhibitory ability. MPT0B390, TIMP3 inducer, inhibits tumor growth, metastasis and angiogenesis. MPT0B390 shows antiproliferative activity against human colon cancer cell line HCT116 with the GI50 of 0.03 μM. MPT0B390 Chemical Structure
  41. GC19936 Quisinostat dihydrochloride Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity. Quisinostat dihydrochloride Chemical Structure
  42. GC64378 Valproic acid-d6 Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid-d6 Chemical Structure
  43. GC64191 Elevenostat Elevenostat (JB3-22) is a selective HDAC11 inhibitor (IC50=0.235??M). Anti-multiple myeloma (MM) activity. Elevenostat Chemical Structure
  44. GC63730 QTX125 TFA QTX125 TFA is a potent and highly selective HDAC6 inhibitor. QTX125 TFA exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects. QTX125 TFA Chemical Structure
  45. GC63703 Ivaltinostat formic Ivaltinostat (CG-200745) formic is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic Chemical Structure
  46. GC49029 CAY17c An inhibitor of BRD4 and class I and class IIb HDACs CAY17c Chemical Structure
  47. GC62430 KA2507 KA2507 is a potent, orally active and selective HDAC6 inhibitor, with an IC50 of 2.5 nM. KA2507 shows antitumor activities and immune modulatory effects in preclinical models. KA2507 Chemical Structure
  48. GC62411 QTX125 QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects. QTX125 Chemical Structure
  49. GC62374 KA2507 monohydrochloride KA2507 hydrochloride is a potent and highly selective inhibitor of HDAC6 (IC50=2.5 nM) with no significant toxicities. KA2507 monohydrochloride Chemical Structure
  50. GC62308 MPT0G211 MPT0G211 is a potent, orally active and selective HDAC6 inhibitor (IC50=0.291?nM). MPT0G211 Chemical Structure
  51. GC61947 Triciferol Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities. Triciferol Chemical Structure
  52. GC48775 AES-350 An inhibitor of class I and class IIb HDACs AES-350 Chemical Structure
  53. GC48460 NR-160 An inhibitor of HDAC6 NR-160 Chemical Structure
  54. GC48408 TW9 A dual inhibitor of BRD4 and HDAC1 TW9 Chemical Structure
  55. GC48084 Sodium 4-Phenylbutyrate-d11 Phenylbutyrate-d11 (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Sodium 4-Phenylbutyrate-d11 Chemical Structure
  56. GC60310 Psammaplin A Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A Chemical Structure
  57. GC39679 CG347B CG347B is a selective HDAC6 inhibitor, also involves in synthesis of other metalloenzyme inhibitors. CG347B Chemical Structure
  58. GC39551 BRD3308 BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 Chemical Structure
  59. GC50322 BRD 9757 Potent and selective HDAC6 inhibitor BRD 9757 Chemical Structure
  60. GC39214 1-Naphthohydroxamic acid 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity.1-Naphthohydroxamic acid can induce tubulin acetylation. 1-Naphthohydroxamic acid Chemical Structure
  61. GC46226 SS-208 An HDAC6 inhibitor SS-208 Chemical Structure
  62. GC38742 BRD-6929 An HDAC1 and HDAC2 inhibitor BRD-6929 Chemical Structure
  63. GC45906 MC1742 An inhibitor of class I and class IIb HDACs MC1742 Chemical Structure
  64. GC45717 Chlamydocin An HDAC inhibitor Chlamydocin Chemical Structure
  65. GA21261 Checkpoint Protein Hus1 (213-232) (human) HDAC1 plays an important role in modulating the eukaryotic chromatin structure and was found to interact specifically in yeast, mammalian cells, and in vitro with the human Hus1 gene product, as reported by Cai and coworkers. The Hus1 protein of S. pombe has been implicated in G2/M checkpoint control and is a member of the cell cycle checkpoint Rad proteins that are involved in the mitotic checkpoint induced by either DNA damage or DNA replication block. Checkpoint Protein Hus1 (213-232) (human) Chemical Structure
  66. GA20567 Ac-Gly-Ala-Lys-AMC Ac-GAK-AMC, control peptide for protease-coupled histone deacetylase (HDAC) assay with Ac-Gly-Ala-Lys(Ac)-AMC (I-1975). Ac-Gly-Ala-Lys-AMC Chemical Structure
  67. GC37845 Tucidinostat An HDAC inhibitor Tucidinostat Chemical Structure
  68. GC37753 Tefinostat Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias. Tefinostat Chemical Structure
  69. GC37643 SIS17 SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM, inhibits the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. SIS17 Chemical Structure
  70. GC36691 Nanatinostat Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM. Nanatinostat Chemical Structure
  71. GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. Nampt-IN-3 Chemical Structure
  72. GC35893 Domatinostat Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Domatinostat Chemical Structure
  73. GC35668 CG-200745 CG-200745 (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG-200745 inhibits deacetylation of histone H3 and tubulin. CG-200745 induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. CG-200745 enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU; ). CG-200745 induces apoptosis and has anti-tumour effects. CG-200745 Chemical Structure
  74. GC35551 BRD 4354 ditrifluoroacetate BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. BRD 4354 ditrifluoroacetate Chemical Structure
  75. GC45095 Tubastatin A (trifluoroacetate salt) Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Tubastatin A (trifluoroacetate salt) Chemical Structure
  76. GC44865 SAHA-BPyne Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. SAHA-BPyne Chemical Structure
  77. GC43806 HC Toxin HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). HC Toxin Chemical Structure
  78. GC43460 Dihydrochlamydocin Dihydrochlamydocin is a cyclic tetrapeptide with putative histone deacetylase (HDAC) inhibitory activity. Dihydrochlamydocin Chemical Structure
  79. GC43318 coumarin-SAHA

    Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.

     coumarin-SAHA Chemical Structure
  80. GC43201 CAY10722 CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). CAY10722 Chemical Structure
  81. GC43200 CAY10721 CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). CAY10721 Chemical Structure
  82. GC43147 CAY10398 CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. CAY10398 Chemical Structure
  83. GC41984 1-Alaninechlamydocin 1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. 1-Alaninechlamydocin Chemical Structure
  84. GC40923 BRD4884 BRD4884 is an HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 μM for HDAC1, 2, and 3, respectively. BRD4884 Chemical Structure
  85. GC40674 APHA Compound 8 A class I and II HDAC inhibitor APHA Compound 8 Chemical Structure
  86. GC34458 ACY-1083

    ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.

     ACY-1083 Chemical Structure
  87. GC34165 Corin Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1. Corin Chemical Structure
  88. GC33331 BRD 4354 BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. BRD 4354 Chemical Structure
  89. GC33290 Remetinostat (SHP-141) Remetinostat (SHP-141) (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma. Remetinostat (SHP-141) Chemical Structure
  90. GC33159 Givinostat hydrochloride (ITF-2357 hydrochloride) Givinostat (ITF-2357) hydrochloride is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride (ITF-2357 hydrochloride) Chemical Structure
  91. GC33115 Pomiferin (NSC 5113) Pomiferin (NSC 5113) (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 μM). Pomiferin (NSC 5113) Chemical Structure
  92. GC33050 Givinostat (ITF-2357) Givinostat (ITF-2357) (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF-2357) Chemical Structure
  93. GC32964 NKL 22 A selective HDAC1/3 inhibitor NKL 22 Chemical Structure
  94. GC32565 CRA-026440 CRA-026440 is a potent, broad-spectrum HDAC inhibitor. CRA-026440 Chemical Structure
  95. GC30782 ACY-775 An HDAC6 inhibitor ACY-775 Chemical Structure
  96. GC30763 Benzenebutyric acid (4-Phenylbutyric acid) Benzenebutyric acid (4-Phenylbutyric acid) (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Benzenebutyric acid (4-Phenylbutyric acid) Chemical Structure
  97. GC30616 3-Hydroxybutyric acid An endogenous and specific inhibitor of class I HDACs 3-Hydroxybutyric acid Chemical Structure
  98. GC19472 Tinostamustine HCl

    An alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule

     Tinostamustine HCl Chemical Structure
  99. GC19384 WT-161 WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM. WT-161 Chemical Structure
  100. GC19360 TMP195 TMP195 is a potent and selective class IIa HDAC inhibitor with IC50s of 59 nM, 60 nM, 26 nM and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively[1]. TMP195 Chemical Structure
  101. GC19337 SR-4370 SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 uM, 0.58 uM, 0.006 uM, 2.3 uM, and 3.4 uM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 Chemical Structure

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  1. Signaling Pathways152
    1. ....Proteases2
      1. ........Endogenous Metabolite2
    2. ....Apoptosis25
      1. ........Apoptosis Inducers1
      2. ........Other Apoptosis20
    3. ....Chromatin/Epigenetics150
      1. ........Bromodomain2
      2. ........DNA Methyltransferase1
      3. ........HDAC145
      4. ........Histone Acetyltransferases1
      5. ........Histone Demethylases4
      6. ........Histone Methyltransferase1
      7. ........JAK1
      8. ........Histone Deacetylation18
      9. ........Histones/Histone Peptides1
    4. ....Metabolism1
      1. ........PDE1
    5. ....Tyrosine Kinase1
      1. ........EGFR1
      2. ........HER21
    6. ....DNA Damage/DNA Repair110
      1. ........HDAC109
      2. ........DNA/RNA Synthesis1
    7. ....PI3K/Akt/mTOR Signaling4
      1. ........mTOR2
      2. ........PI3K2
    8. ....Microbiology & Virology10
      1. ........HIV6
      2. ........Bacterial1
      3. ........Parasite1
      4. ........Virus Protease2
    9. ....Cell Cycle/Checkpoint1
    10. ....Ubiquitination/ Proteasome17
      1. ........Autophagy17
      2. ........Mitophagy4
    11. ....JAK/STAT Signaling2
      1. ........EGFR1
      2. ........JAK1
    12. ....Stem Cell3
      1. ........Notch3
    13. ....Cancer Biology1
    14. ....Neuroscience2
    15. ....Immunology/Inflammation3
      1. ........Apoptosis1
      2. ........Adaptive Immunity1
      3. ........Immunotherapeutics1
    16. ....Vitamin D Related1
      1. ........VD/VDR1
    17. ....Toxins1
  2. Natural Products1
  3. Peptides3
  4. Infectious Disease1
    1. ....Viral Diseases1
      1. ........HIV1
  5. Plant Biology1
    1. ....Phytotoxins1