Cecropin A (trifluoroacetate salt) |
Catalog No.GC52378 |
An antimicrobial peptide
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Cecropin A is an antimicrobial peptide that has been found in H. cecropia.1,2 It induces apoptosis in C. albicans when used at a concentration of 5 µM.2 Cecropin A is active against the planktonic and uropathogenic E. coli strain CFT073 (MIC = 100 µg/ml) and increases survival of CFT073-infected G. mellonella larvae.1 Cecropin A (15 mg/kg) decreases enrichment of the gut microflora Bacteroidaceae and Enterobacteriaceae and increases gut levels of Lactobacillus, as well as increases survival and decreases body weight loss in a mouse model of inflammatory bowel disease (IBD) induced by dextran sulfate .3
1.Kalsy, M., Tonk, M., Hardt, M., et al.The insect antimicrobial peptide cecropin A disrupts uropathogenic Escherichia coli biofilmsNPJ Biofilms Microbiomes6(1)6(2020) 2.Yun, J., and Lee, D.G.Cecropin A-induced apoptosis is regulated by ion balance and glutathione antioxidant system in Candida albicansIUBMB Life68(8)652-662(2016) 3.Zhai, Z., Zhang, F., Cao, R., et al.Cecropin A alleviates inflammation through modulating the gut microbiota of C57BL/6 mice with DSS-induced IBDFront. Microbiol.101595(2019)
Cas No. | SDF | Download SDF | |
Canonical SMILES | OC(C(F)(F)F)=O.[H]NCCCC[C@H](NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CCCCN[H])N[H])=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(NCC(N[C@@](C(N[C@@](C(N[C@@H](CCCCN[H])C(N[C@H](C(NCC(N3CCC[C@H]3C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@]([H])([C@@H](C)O)C(N[C@@H](CCC(N)=O)C(N[C@@](C(N[C@H](C(N[C@@H](CCCCN[H])C(N)=O)=O)C)=O)([H])[C@H](CC)C)=O)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O)C)=O)=O)=O)C)=O)=O)([H])[C@H](CC)C)=O)([H])[C@H](CC)C)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)=O)CC4=CC=CC=C4)=O)CC(C)C)=O | ||
Formula | C184H313N53O46 ? XCF3COOH | M.Wt | 4003.8 |
Solubility | Water: soluble | Storage | -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 0.2498 mL | 1.2488 mL | 2.4976 mL |
5 mM | 0.05 mL | 0.2498 mL | 0.4995 mL |
10 mM | 0.025 mL | 0.1249 mL | 0.2498 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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