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Cefadroxil (hydrate) Catalog No.GC16253

broad-spectrum antibiotic

Size Price Stock Qty
10mM (in 1mL DMSO)
$36.00
In stock
250mg
$63.00
In stock
500mg
$116.00
In stock
1g
$226.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

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Chemical Properties

Cas No. 66592-87-8 SDF
Synonyms Duricef,Bidocel
Chemical Name (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monohydrate
Canonical SMILES OC1=CC=C([C@@H](N)C(N[C@@H]2C(N3[C@]2([H])SCC(C)=C3C(O)=O)=O)=O)C=C1.O
Formula C16H17N3O5S • H2O M.Wt 381.4
Solubility ≥ 5.8mg/mL in DMSO with gentle warming Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Cefadroxil is a new semisynthetic cephalosporin with a broad antibacterial spectrum and a high chemotherapeutic potential [1].

In vitro: The inhibitory activity of this compound was similar to that of cephalexin and cephradine when tested against 602 clinical isolates on Mueller-Hinton medium. In the oral treatment of experimental infections of mice, cefadroxil was more effective than cephalexin against Streptococcus pyogenes, and comparably effective against Streptococcus pneumoniae, Staphylococcus aureus, and several gram-negative species [1].

In vivo: In mice, oral administration of cefadroxil at doses ranging from 25 to 100 mg/kg attained peak concentrations in the blood. Higher peak levels were noted with cefadroxil than with cephalexin at a dose of 200 mg/kg [1].

Clinical trials: A single daily dose of cefadroxil appeared to be as effective in the treatment of patients with A β-hemolytic streptococcal (GABHS) pharyngitis [2].

References:
[1] Buck R E, Price K E.  Cefadroxil, a new broad-spectrum cephalosporin[J]. Antimicrobial agents and chemotherapy, 1977, 11(2): 324-330.
[2] Gerber M A, Randolph M F, Chanatry J, et al.  Once daily therapy for streptococcal pharyngitis with cefadroxil[J]. The Journal of pediatrics, 1986, 109(3): 531-537.