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Cerevisterol

Catalog No.GC45716

A fungal metabolite

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Cerevisterol Chemical Structure

Cas No.: 516-37-0

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1mg
$683.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Cerevisterol is an ergosterol fungal metabolite originally isolated from S. cerevisiae that has diverse biological activities, including antimicrobial, anti-inflammatory, and anticancer properties.1 It is active against the bacteria S. typhi, S. aureus, and E. faecalis (MICs = 25, 25, and 50 μg/ml, respectively) and the fungus A. niger (MIC = 25 μg/ml), but has no effect on the bacteria E. coli, P. aeruginosa, S. pyogenes, K. pneumoniae, and B. subtilis, or the fungi C. albicans, A. flavus, and A. tamarii when used at concentrations up to 400 μg/ml.2 Cerevisterol (2-20 μM) inhibits LPS-induced increases in the levels of nitric oxide (NO), TNF-α, IL-6, IL-10, and prostaglandin E2 in RAW 264.7 cells.3 It inhibits proliferation of MCF-7, MDA-MB-231, and Caco-2 cancer cells (EC50s = 64.5, 52.4, and 37.6 μM, respectively), but not PC3, PANC-1, or A549 cells (IC50 = >100 μM for all).4,5

|1. Bills, C.E., and Honeywell, E.M. Antiricketic substances: VIII. Studies on highly purified ergosterol and its esters. J. Biol. Chem. 80, 15-23 (1928).|2. Appiah, T., Agyare, C., Luo, Y., et al. Antimicrobial and resistance modifying activities of cerevisterol isolated from Trametes species. Curr. Bioact. Compd. 14, (2018).|3. Liu, Y.-W., Mei, H.-C., Su, Y.-W., et al. Inhibitory effects of Pleurotus tuber-regium mycelia and bioactive constituents on LPS-treated RAW 264.7 cells. J. Funct. Foods 7, 662-670 (2014).|4. Wang, H., Liu, T., and Xin, Z. A new glucitol from an endophytic fungus Fusarium equiseti Salicorn 8. Eur. Food Res. Technol. 239(3), 365-376 (2014).|5. Wang, Q.-X., Li, S.-F., Zhao, F., et al. Chemical constituents from endophytic fungus Fusarium oxysporum. Fitoterapia 82(5), 777-781 (2011).

Chemical Properties

Cas No. 516-37-0 SDF
Canonical SMILES C[C@H](/C=C/[C@H](C)C(C)C)[C@@]1([H])CC[C@@]2([H])C3=C[C@@H](O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Formula C28H46O3 M.Wt 430.7
Solubility DMSO: soluble,Ethanol: soluble,Methanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3218 mL 11.609 mL 23.218 mL
5 mM 0.4644 mL 2.3218 mL 4.6436 mL
10 mM 0.2322 mL 1.1609 mL 2.3218 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 40 reference(s) in Google Scholar.)

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