Chloramphenicol |
| Catalog No.: GC15185 |
An acetylated version of chloramphenicol
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
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Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Chloramphenicol is a broad-spectrum antibiotic against bacterial infections.
References:
[1]. Jardetzky, O., Studies on the mechanism of action of chloramphenicol. I. The conformation of chlioramphenicol in solution. J Biol Chem, 1963. 238: p. 2498-508.
[2]. Wolfe, A.D. and F.E. Hahn, Mode of Action of Chloramphenicol. Ix. Effects of Chloramphenicol Upon a Ribosomal Amino Acid Polymerization System and Its Binding to Bacterial Ribosome. Biochim Biophys Acta, 1965. 95: p. 146-55.
| Cas No. | 56-75-7 | SDF | |
| Chemical Name | 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide | ||
| Canonical SMILES | C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-] | ||
| Formula | C11H12Cl2N2O5 | M.Wt | 323.13 |
| Solubility | ≥ 16.16 mg/mL in DMSO, ≥ 16.25 mg/mL in Water with ultrasonic and warming, ≥ 33 mg/mL in EtOH | Storage | Store at 2-8°C,unstable in solution, ready to use. |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Chloramphenicol
IARC Monogr Eval Carcinog Risks Hum 1990;50:169-93.2292798 PMC7682317
Chloramphenicol
Med Clin North Am 1982 Jan;66(1):91-102.7038343 10.1016/s0025-7125(16)31444-4
Chloramphenicol
Pediatr Clin North Am 1968 Feb;15(1):57-72.4866907 10.1016/s0031-3955(16)32088-0
Chloramphenicol toxicity
Adverse Drug React Toxicol Rev 1993 Summer;12(2):83-95.8357947
Although high serum concentrations of Chloramphenicol are related to toxicity, as shown experimentally and during treatment, the mechanism of toxicity remains unclear. Published work suggests that relatively minor metabolites may be causally related to toxic reactions in vitro and some of these metabolites have been detected in sera from treated patients. It is possible that all the major toxic manifestations of Chloramphenicol may be explained by attack by free radicals. Depletion in compounds acting as cellular antioxidants, such as glutathione and vitamin E, may conceivably increase the vulnerability of an individual to Chloramphenicol toxicity, while supplementation with an antioxidant might protect against it. Research into the metabolism of Chloramphenicol and into the mechanism of its toxicity has declined since early work in the 1950s and 1960s, but its continuing use worldwide means that there is justification for renewed interest in the toxicology of this useful antibiotic.
Chloramphenicol: what we have learned in the last decade
South Med J 1986 Sep;79(9):1129-34.3529436
Chloramphenicol is a unique antibiotic. The kinetics and efficacy of the oral and intravenous preparations are comparable. Chloramphenicol is usually bacteriostatic but is bactericidal against Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis, and Chloramphenicol's clinical efficacy against these meningeal pathogens is well established. Chloramphenicol can be used to treat serious pediatric infections when Haemophilus influenzae is a likely pathogen, as well as typhoid fever, anaerobic infections, bacterial meningitis in patients allergic to penicillin, brain abscesses, and rickettsial infections. The use of Chloramphenicol is limited because of its toxicity. Aplastic anemia is very rare but can occur after either oral or intravenous administration. The gray syndrome can be eliminated and marrow suppression minimized by using Chloramphenicol at the recommended doses and monitoring levels. During the last decade the increased use of Chloramphenicol has not resulted in increased resistance or in frequent reports of toxicity. Thus, Chloramphenicol remains an important inpatient antibiotic that can be invaluable for treating certain life-threatening infections.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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