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CHPG Sodium salt

Catalog No.GC17963

mGlu5 agonist

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CHPG Sodium salt Chemical Structure

Cas No.: 1303993-73-8

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10mg
$162.00
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50mg
$540.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2].

CHPG sodium salt (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment[1]. CHPG sodium salt (0.5 mM; 30 mins ) protects BV2 cells against SO2-induced apoptosis[1]. CHPG sodium salt (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels[1].

CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume[2].

References:
[1]. Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52.
[2]. Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6.

Chemical Properties

Cas No. 1303993-73-8 SDF
Chemical Name sodium (R)-2-amino-2-(2-chloro-5-hydroxyphenyl)acetate
Canonical SMILES ClC(C=C1)=C(C=C1O)[C@H](C([O-])=O)N.[Na+]
Formula C8H7ClNNaO3 M.Wt 223.59
Solubility Soluble in DMSO Storage Store at RT
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.4725 mL 22.3624 mL 44.7247 mL
5 mM 0.8945 mL 4.4725 mL 8.9449 mL
10 mM 0.4472 mL 2.2362 mL 4.4725 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 31 reference(s) in Google Scholar.)

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