Chroman 1 (hydrochloride hydrate) (Synonyms: (S)-Chroman 1) |
| Catalog No.GC49334 |
A ROCK2 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Chroman 1 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = <1 nM).1 It is selective for ROCK2 over protein kinase A (PKA) and Cdc42-binding kinase (MRCKα; IC50s = 1,740 and 127 nM, respectively). Chroman 1 inhibits phosphorylation of myosin light chain (MLC) in a cell-based assay (IC50 = <4 nM).
1.Chen, Y.T., Vojkovsky, T., Fang, X., et al.Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitorsMed. Chem. Commun.2(1)73-75(2011)
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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