CIQ |
| Catalog No.GC14414 |
NMDA receptor potentiator
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 486427-17-2
Sample solution is provided at 25 µL, 10mM.
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CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. IC50 value: 2.7 μM (EC50, for NR2C) and 2.8 μM (EC50, NR2D)Target: NMDA receptorCIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 μM, respectively), with no effect on NR2A or NR2B subtypes. CIQ does not alter the EC50 values for glutamate or glycine on channel opening. CIQ increases channel opening efficiency and enhances NMDA receptor responses. CIQ reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinson's disease models.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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