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cis-ACCP

Catalog No.GC10149

type IV collagen-specific MMP-2 and MMP-9 inhibitor

Products are for research use only. Not for human use. We do not sell to patients.

cis-ACCP Chemical Structure

Cas No.: 777075-44-2

Size Price Stock Qty
1mg
$40.00
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5mg
$170.00
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10mg
$303.00
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50mg
$1,321.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

IC50: 4 and 20 μM for MMP-2 and MMP-9, respectively

cis-ACCP is a type IV collagen-specific MMP-2 and MMP-9 inhibitor.

Matrix metalloproteinases (MMPs) belong to a family of proteases that play a keyrole in tissue remodeling and repair via degrading extracellular matrix proteins, therefore enabling cell migration.

In vitro: cis-ACCP could preferentially inhibit MMP-2 and MMP-9 with a preference for MMP-2. The trans-ACCP did not inhibit the gelatinases but had moderate activity against MMP-3 and MMP-13. These findings indicated specificity of the compounds regarding binding to the enzymes. Furthermore, addition of cis-ACCP to tumor cells was able to prevent their traversion dose-dependently, about 90% at the highest concentration tested [1].

In vivo: Aninmal study showd that cis-ACCP could reduce metastasis formation in mice by approximately 90% when administered by a repetitive once daily dosing regimen at 50 mg/kg via oral or i.p. routes and was nontoxic up to 500 mg/kg, following i.p. administration daily for two weeks. In addition, the pharmacokinetic investigation in rats revealed distribution restricted into the extracellular fluid, the site of action for the antimetastatic activity and rapid elimination from blood [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Hoffman, A. ,Qadri, B.,Frant, J., et al. Carbamoylphosphonate matrix metalloproteinase inhibitors 6: Cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor-synthesis and pharmacodynamic and pharmacokinetic analysis. Journal of Medicinal Chemistry 51, 1406-1414 (2008).

Chemical Properties

Cas No. 777075-44-2 SDF
Chemical Name P-[[[(1R,2S)-2-aminocyclohexyl]amino]carbonyl]-phosphonic acid
Canonical SMILES N[C@H]1CCCC[C@H]1NC(P(O)(O)=O)=O
Formula C7H15N2O4P M.Wt 222.2
Solubility ≤0.15mg/ml in ethanol;0.3mg/ml in PBS, pH 7.2, Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.5005 mL 22.5023 mL 45.0045 mL
5 mM 0.9001 mL 4.5005 mL 9.0009 mL
10 mM 0.45 mL 2.2502 mL 4.5005 mL
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 9 reference(s) in Google Scholar.)

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