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Clavulanate (potassium salt) (Synonyms: BRL 14151K)

Catalog No.GC15637

β-lactamase inhibitor

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Clavulanate (potassium salt) Chemical Structure

Cas No.: 61177-45-5

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25mg
$38.00
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50mg
$47.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Clavulanate is a metabolite existed in cultures of Streptomyces clavuligerusa with activity against both Gram-positive and Gram-negative bacteria. Clavulanate is a first clinically useful broad-spectrum β-lactamase inhibitor. Clavulanate formulations have been widely used in the treatment of a broad range of clinical infections [1].

Clavulanate was least active against Pseudomonas spp. and the enterococci with MICs of 125–512 mg/L, followed by members of the Enterobacteriaceae and H. influenzae with MICs of 12–125 mg/L. Clavulanate showed great activity against Bacteroides spp. and other anaerobes, M. catarrhalis, staphylococci and streptococci with MICs of 4–50 mg/L. Clavulanate was active against Neisseria spp. with MICs of 1.25–4 mg/L [1].

In an infection model of L. pneumophila pneumonia leucopenic weanling rats, clavulanate effectively prevented the development of infection. In a mouse lethal thigh infection model with two susceptible strains of S. pneumoniae, treatment with clavulanate decreased the mortality [1].

Reference:
[1] Finlay J, Miller L, Poupard J A.  A review of the antimicrobial activity of clavulanate[J]. Journal of Antimicrobial Chemotherapy, 2003, 52(1): 18-23.

Chemical Properties

Cas No. 61177-45-5 SDF
Synonyms BRL 14151K
Chemical Name (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monopotassium salt
Canonical SMILES O=C1C[C@]2([H])N1[C@@H](C([O-])=O)/C(O2)=C/CO.[K+]
Formula C8H8NO5 • K M.Wt 237.3
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.2141 mL 21.0704 mL 42.1408 mL
5 mM 0.8428 mL 4.2141 mL 8.4282 mL
10 mM 0.4214 mL 2.107 mL 4.2141 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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