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Prothrombin (474-477) [Mus musculus]

Catalog No.GP10053

Prothrombin (474-477) [Mus musculus] Chemical Structure

Role in coagulation cascade

Size Price Stock Qty
Coagulation factor II peptide; prothrombin (474-477) [Mus musculus] 1mg
$27.00
In stock
Coagulation factor II peptide; prothrombin (474-477) [Mus musculus] 5mg
$89.00
In stock
Coagulation factor II peptide; prothrombin (474-477) [Mus musculus] 10mg
$142.00
In stock
Coagulation factor II peptide; prothrombin (474-477) [Mus musculus] 25mg
$191.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Prothrombin (coagulation factor II) (H2N-Tyr-Ile-His-Pro-OH) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid (Gla).

Prothrombin is proteolytically cleaved to form thrombin in the coagulation cascade, which ultimately results in the stemming of blood loss. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. [1]

Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin have been described (e.g., hypoprothrombinemia). Anti-prothrombin antibodies in autoimmune disease may be a factor in the formation of the lupus anticoagulant, also known as antiphospholipid syndrome. Hyperprothrombinemia can be caused by the G20210A mutation. Thus, manipulation of prothrombin is central to the mode of action of most anticoagulants.

References:
1. Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somat. Cell Mol. Genet. 13 (3): 285–92.

Chemical Properties

Cas No. N/A SDF
Synonyms H2N-Tyr-Ile-His-Pro-OH
Chemical Name N/A
Canonical SMILES OC1=CC=C(C[C@H](N)C(N[C@@H]([C@H](C)CC)C(NC(CC2=CNC=N2)C(N3CCC[C@]3([H])C(O)=O)=O)=O)=O)C=C1
Formula C26H36N6O6 M.Wt 528.6
Solubility ≥ 52.9mg/mL in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Review for Prothrombin (474-477) [Mus musculus]

Average Rating: 5 ★★★★★ (Based on Reviews and 21 reference(s) in Google Scholar.)

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