Home>>Collismycin A
Collismycin A Catalog No.GC43299

A bacterial metabolite with diverse biological activities

Size Price Stock Qty
1mg
$422.00
In stock
5mg
$1,266.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 158792-24-6 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES COC1=C(SC)C(/C=N/O)=NC(C2=NC=CC=C2)=C1
Formula C13H13N3O2S M.Wt 275.3
Solubility DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs = 6.25 and 100 µg/ml) and fungi (MICs = 12.5-100 µg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 µM, respectively) and NIH373 fibroblasts (IC50 = 56.6 µM) but not MDA-MD-231 breast cancer cells (IC50 = >100 µM). Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions. Collismycin A (1 µM) prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of neuronal cell death induced by all-trans retinoic acid .