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(+)-Corynoline Catalog No.GN10654

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20mg
$167.00
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Sample solution is provided at 25 µL, 10mM.

Quality Control

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Chemical Properties

Cas No. 18797-79-0 SDF
Chemical Name 5b,13-dimethyl-5b,6,7,12b,13,14-hexahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol
Canonical SMILES [H]C1(C2=C([H])C3=C4OC([H])([H])O3)N(C([H])([H])[H])C([H])([H])C5=C(C([H])=C([H])C6=C5OC([H])([H])O6)C1(C([H])([H])[H])C(C([H])([H])C2=C4[H])([H])O[H]
Formula C21H21NO5 M.Wt 367.14
Solubility Chloroform: 10 mg/ml,DMF: slightly soluble,Ethanol: slightly soluble Storage
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].

References:
[1]. Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9.
[2]. Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.